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I do not foresee any potential interactions between the Evening Primrose Oil and your Metformin. There is nothing in the literature to suggest that this is a possibility. In fact, Evening Primrose Oil is something I commonly prescribe for women with PCOS. It is known to naturally help improve the balance between progesterone and estrogen. An elevated ratio of Estrogen to Progesterone is commonly seen in women ...
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Wild Yam can be helpful for balancing certain issues related to female hormones. It is thought to do this by gently stimulating certain receptors on cells that are related to hormones like estrogen and progesterone. Although this herb can have gentle hormonal like action on the cells it is not likely strong enough to influence cellular activity enough to change breast size.
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