Cholesterol (low)

Table of Contents

Other names

Hypocholesterolemia
Low Blood Cholesterol
Decreased Serum Cholesterol

Synopsis

Low cholesterol, or hypocholesterolemia, refers to abnormally low levels of cholesterol in the blood, typically total cholesterol below 120 mg/dL or LDL cholesterol below 50–60 mg/dL. While high cholesterol is well known for its cardiovascular risks, very low cholesterol can also be harmful. Cholesterol is essential for building cell membranes, producing hormones (like estrogen, testosterone, and cortisol), synthesizing vitamin D, and aiding digestion through bile acid production.

Persistently low cholesterol levels have been linked to increased risks of certain health issues, including depression, anxiety, hemorrhagic stroke, hormonal imbalances, weakened immune function, and poor nutrient absorption. It may also signal underlying conditions that need medical attention.

Types of Low Cholesterol:

  • Primary Hypocholesterolemia: Rare genetic conditions like abetalipoproteinemia or familial hypobetalipoproteinemia.

  • Secondary Hypocholesterolemia: Result of other medical conditions, malnutrition, or aggressive cholesterol-lowering therapy.

Common Causes:

  • Hyperthyroidism (overactive thyroid)

  • Liver disease (e.g., cirrhosis, cancer)

  • Malnutrition or eating disorders (anorexia, severe malabsorption)

  • Chronic infections (e.g., tuberculosis, HIV/AIDS)

  • Certain cancers (particularly gastrointestinal or hematological)

  • Overmedication with statins or other lipid-lowering drugs

  • Genetic disorders affecting lipid metabolism

Severity Factors:

  • Extremely low LDL cholesterol (<40 mg/dL) associated with risks of hemorrhagic stroke and mental health disturbances.

  • Severe malnutrition or chronic disease states increase morbidity associated with hypocholesterolemia.

  • Low cholesterol affecting hormone production can result in fatigue, reproductive issues, and adrenal insufficiency.

When to See a Doctor:

  • Routine blood work showing unexpectedly low cholesterol

  • Symptoms like fatigue, depression, hormonal problems, or bleeding tendencies

  • History of malnutrition, chronic illness, or aggressive cholesterol-lowering therapy

  • Unintentional weight loss, digestive issues, or chronic infections

Natural Remedies

Balanced diet: Include healthy fats like olive oil, avocados, nuts, and seeds to maintain adequate cholesterol levels.

Increase protein intake: Supports muscle mass and hormone production.

Moderate carbohydrate intake: Focus on whole grains, fruits, and vegetables.

Correct nutrient deficiencies: Ensure adequate intake of vitamins A, D, E, and K (fat-soluble vitamins needing cholesterol for absorption).

Avoid overuse of cholesterol-lowering supplements or medications without medical supervision.

Manage underlying conditions: Address infections, thyroid dysfunction, or digestive problems.

Reduce chronic stress: Support adrenal and hormonal balance.