Progesterone (low)

Table of Contents

Other names

Luteal phase deficiency
Progesterone insufficiency
Hormonal imbalance (low progesterone)

Synopsis

Low progesterone refers to insufficient levels of this key reproductive hormone, especially during the luteal phase of the menstrual cycle or in early pregnancy. Progesterone plays a vital role in regulating the menstrual cycle, supporting implantation, maintaining pregnancy, and balancing the effects of estrogen. When levels are too low, it can result in irregular or short cycles, fertility issues, premenstrual symptoms, anxiety, and poor sleep. In pregnancy, low progesterone may contribute to miscarriage or early pregnancy loss. This condition is often underdiagnosed but can be identified through hormone testing and cycle tracking.

Types:

  • Luteal phase defect: Inadequate progesterone production after ovulation

  • Menopausal transition: Naturally declining levels during perimenopause

  • Pregnancy-related deficiency: Insufficient progesterone to support early pregnancy

  • Functional deficiency: Low levels due to stress, poor diet, or chronic inflammation

Common Causes:

  • Anovulation or irregular ovulation

  • Chronic stress and elevated cortisol

  • Thyroid disorders or insulin resistance

  • Overexposure to environmental estrogens (xenoestrogens)

  • Underweight or excessive exercise

  • Perimenopause or early menopause

Severity Causes:

  • Long-term estrogen dominance increasing endometrial cancer risk

  • Miscarriage or difficulty maintaining pregnancy

  • Mood swings, anxiety, or severe PMS

  • Poor sleep due to low GABA activity (modulated by progesterone)

  • Heavy or irregular menstrual bleeding

When to See a Doctor:

  • Irregular or very short menstrual cycles

  • Fertility challenges or recurrent miscarriage

  • Severe PMS, anxiety, or sleep disturbances

  • Diagnosed estrogen dominance or low basal body temperature post-ovulation

  • Suspicion of perimenopausal hormone shift

Natural Remedies

Vitex (chaste tree): Stimulates the pituitary gland to increase luteinizing hormone (LH), which supports natural progesterone production in the luteal phase. Best taken for several cycles.

Magnesium: Supports adrenal function and hormone synthesis. Low levels contribute to stress-driven progesterone suppression and PMS symptoms.

Vitamin B6: Essential for corpus luteum function and progesterone formation. Combined with magnesium, it improves mood and hormone balance.

Ashwagandha: An adaptogen that reduces cortisol and helps restore HPA-axis balance, indirectly supporting ovulation and progesterone levels.

Maca: A Peruvian root that supports endocrine function and may improve progesterone-to-estrogen ratio without containing hormones.

Zinc: Plays a critical role in ovarian function and hormone regulation. Deficiency can impair ovulation and reduce progesterone production.

Healthy fats: Including omega-3s and cholesterol from whole foods helps form the raw materials for hormone synthesis, especially post-ovulation.

Sleep hygiene: Adequate rest and consistent circadian rhythms support adrenal and ovarian function, both essential for progesterone production.

Ingredients

These raw ingredients are often used in alternative medicine to treat this condition.

ashwagandha
vitamin B6
vitamin C
vitamin D
zinc
chaste tree
maca
magnesium
omega-3 fatty acids