Equol (proprietary) (Equol )
Synopsis
Equol is a nonsteroidal, estrogen-like compound that is produced in the human gut from the metabolism of daidzein, a major isoflavone found in soybeans and soy products. It belongs to the class of phytoestrogens and is structurally similar to estradiol, allowing it to bind to estrogen receptors, especially ER-β (estrogen receptor beta). Equol itself is not found in soy foods—it is a metabolite, and only about 30–50% of people have the necessary gut bacteria to produce it naturally.
Proprietary equol supplements contain synthetically produced or fermentation-derived S-equol, the biologically active enantiomer that mimics some of the beneficial effects of estrogen without stimulating estrogen-sensitive tissues, making it safer than hormone therapy for some users.
Benefits of equol supplementation may include:
- Relief of menopausal symptoms, especially hot flashes, night sweats, and mood swings
- Bone health support, helping reduce postmenopausal bone loss
- Skin elasticity and hydration improvement, often included in anti-aging regimens
- Cardiovascular benefits, including possible reductions in arterial stiffness and LDL oxidation
- Prostate health support in men, particularly for benign prostatic hyperplasia (BPH), due to its ability to bind dihydrotestosterone (DHT) and reduce its activity
Equol is typically delivered in capsules or tablets as a standardized, proprietary ingredient (e.g., S-equol from fermentation of daidzein by specific probiotic strains). It is especially popular in menopause support formulas, hormone-balancing supplements, and skin health products.
Historical Use
While equol itself was discovered in the 1980s, and synthetic forms were developed only in the 21st century, its precursors—soy isoflavones—have a long-standing role in traditional Asian diets and medicine.
In traditional Chinese and Japanese medicine, soy foods like tofu, miso, and natto were consumed regularly and were thought to:
- Balance internal energy (yin and yang)
- Promote digestive and hormonal health
- Improve female reproductive function and postnatal recovery
The lower incidence of menopausal symptoms, osteoporosis, and hormone-sensitive cancers in populations with soy-rich diets led researchers to explore the bioactive metabolites, ultimately identifying equol as one of the key protective agents—but only in people capable of producing it.
Today, proprietary equol supplements are designed to deliver the benefits of isoflavone metabolism even in non-converters, especially targeting:
- Menopausal and perimenopausal women
- Aging men with prostate concerns
- Individuals seeking natural, non-hormonal alternatives to HRT
Proprietary forms of equol are used in nutraceuticals, functional foods, and clinical research, often paired with calcium, vitamin D, collagen, or other hormone-modulating ingredients for synergistic support.
Body Systems
Breasts (Traditional)
Circulatory System (Traditional)
Prostate (Traditional)
Skin (Traditional)