Grape (Vitis vinifera)
Synopsis
Vitis vinifera, commonly known as grape, is a fruit-bearing vine native to the Mediterranean region and Central Asia and cultivated worldwide. Both the fruit, seeds, and skin of grapes—especially red and purple varieties—contain potent phytonutrients, including resveratrol, proanthocyanidins, anthocyanins, flavonoids, and tartaric acid, along with vitamin C, potassium, and manganese. These compounds are associated with cardiovascular protection, antioxidant activity, and cellular health.
In modern herbal and nutritional science, grapes are primarily valued for their antioxidant and anti-inflammatory effects, which help protect against oxidative stress, atherosclerosis, hypertension, and age-related cognitive decline. Grape seed extract (GSE), in particular, is a concentrated source of oligomeric proanthocyanidins (OPCs) and is used in supplements to support capillary integrity, reduce inflammation, and promote healthy circulation. Resveratrol, found in grape skins (and famously in red wine), is studied for its role in longevity, metabolic regulation, and neuroprotection.
Grapes and grape extracts are often included in products for heart health, skin rejuvenation, vision support (due to their effect on retinal blood vessels), and immune modulation. Both fresh grapes and their extracts are used in functional foods, juices, supplements, and skincare products.
Historical Use
Grapes have been cultivated for over 6,000 years, with early use recorded in ancient Egypt, Mesopotamia, Greece, and Rome, not only as food but also as medicine and sacred offerings. The Greeks and Romans used grapes for their digestive and diuretic properties, and fermented grapes (wine) were considered both a stimulant and a medicinal agent, often used in tinctures and medicinal wines to extract the healing properties of herbs.
In Ayurveda, dried grapes (raisins) are considered cooling, sweet, and rejuvenating, used to pacify Pitta, nourish the blood, and treat fevers, constipation, and lung conditions. They are also used in tonics to build stamina and calm inflammation. Grapes are included in classical formulas like Draksharishta, a fermented grape tonic for digestive and respiratory support.
In Traditional Chinese Medicine (TCM), grapes are used to tonify Qi and blood, moisten dryness, and support the Liver and Kidney systems, often for symptoms like fatigue, dry cough, and weakness.
Today, grapes remain a symbol of health and longevity, and their derivatives—particularly grape seed extract and resveratrol—are widely used in evidence-based wellness strategies focused on vascular health, cellular defense, and graceful aging.
Uses: Health Conditions
Cataracts (Traditional)
Cellulite (Traditional)
Cervical Dysplasia (Traditional)
Chemical Poisoning (Traditional)
Chemotherapy (reducing side effects) (Traditional)
Chest Pain (Traditional)
Chicken Pox (Traditional)
Chills (Traditional)
Cholesterol (high) (Traditional)
Cholesterol (low) (Traditional)
Chronic Obstructive Pulmonary Disorder (Traditional)
Circulation (poor) (Traditional)
Circulation (to the brain) (Traditional)
Cold Hands and Feet (Traditional)
Colds (antiviral) (Traditional)
Colds (general) (Traditional)
Colds (prevention) (Traditional)
Colds (with fever) (Traditional)
Concentration (poor) (Traditional)
Concussions (Traditional)
Confusion (Traditional)
Congestion (Traditional)
Congestion (bronchial) (Traditional)
Congestion (lungs) (Traditional)
Congestion (lymphatic) (Traditional)
Congestion (sinus) (Traditional)
Congestive Heart Failure (Traditional)
Conjunctivitis (Traditional)
Constipation (children) (Traditional)
Contagious Diseases (Traditional)
Convalescence (Traditional)
Copper Toxicity (Traditional)
Cough (general) (Traditional)
Cough (spastic) (Traditional)
Cradle Cap (Traditional)
Cramps (leg) (Traditional)
Cramps (menstrual) (Traditional)
Cramps and Spasms (Traditional)
Cushing's Disease (Traditional)
Cuts (Traditional)
Cystic Fibrosis (Traditional)
Cysts (Traditional)
Cytomealovirus (Traditional)
Deafness (Traditional)
Debility (Traditional)
Defensiveness (Traditional)
Dementia (Traditional)
Depression (Traditional)
Dermatitis (Traditional)
Diabetes (Traditional)
Diabetic Retinopathy (Traditional)
Nose Bleeds (Traditional)
Phlebitis (Traditional)
Body Systems
Arteries (Traditional)
Circulatory System (Science)
Immune System (Science)
Mitochondria (Science)
Skin (Science)
Products containing this ingredient
Vitabase
Active Man's Formula
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Athletic Nutrients
Douglas Laboratories
Berberine Balance
Designs For Health
BergaVin™ 60 capsules
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Bilberry Extract Plus
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Ceralin® Forte
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Cholesterol Support
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CurcumaSorb Mind
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Detox Antiox™
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Detoxication Factors
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Detoxication Factors
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Detoxification Support Packets
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DopaPlus
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EHB
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EssentiaGreens™
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Glucosamine + MSM Forte ™
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Glucosamine Plus ™
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Grape Pip 500 mg
Vitabase
Grape Seed Extract
Thorne
Grape Seed Extract O.P.C.-100
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Grape Seed Supreme™
Douglas Laboratories
Hair Growth+
Pure Encapsulations
Hair/Skin/Nails Ultra
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HTN Supreme™
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Juvenon Pro Cognitive
Klean Athlete
Klean Focus®
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Life's Essentials Plus
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Macular Support Formula
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Macular Support Formula
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MediClear Plus
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Optimized Curcumin With Neurophenol™
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PaleoCleanse Plus™
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PaleoCleanse Plus™
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PaleoCleanse Plus™ Detox Program
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PaleoCleanse Plus™Chocolate Detox Kit
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PaleoGreens®
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PaleoGreens®
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PaleoReds®
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PhytoBiome™
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PhytoMulti™ Multivitamin
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PhytoMulti With Iron
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PhytoMulti Without Iron
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PhytoMultivitamin
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Plant Protein Cleanse Plus™ 570g
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Polyphenol Nutrients
Pure Encapsulations
Polyphenol Nutrients
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Primal Multi™
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Resveratrol Extra
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Resveratrol Extra
Integrative Therapeutics
Resveratrol Ultra HP 175mg
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Senolytic Synergy
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Ultimate Antiox Full Spectrum
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Ultra Benfotiamine
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Ultra Preventive
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Ultra Preventive
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Ultra Preventive ®-EZ Swallow
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Ultra Preventive® X
Pure Encapsulations
Ultra Pure Pack
Pure Encapsulations
Uric Acid Formula
Douglas Laboratories
Uro-Pro ®
Pure Encapsulations
Vascular Relax
Designs For Health
Vessel Forte™
Vitabase
Vision Support
Metagenics
Wellness Essentials Active Daily Packs
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Wellness Essentials Brain Health Daily Packs
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Wellness Essentials® Daily Packs
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Wellness Essentials Healthy Balance Daily Packs
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Wellness Essentials Men's Vitality Daily Packs
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Wellness Essentials Women's Daily Packs
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Wellness Essentials Women's Prime Daily Packs
Pure Encapsulations
Women's Nutrients