Alpha-Ketoglutarate
Other names for Alpha-Ketoglutarate
akg
& alpha-ketoglutarate
alpha keto glutarate
alpha ketoglutarate
alpha-keto glutarate
alpha-ketoglutarate
alpha keto glutaric acid
alpha ketoglutaric acid
alpha-keto glutaric acid
alpha-ketoglutaric acid
alpha-ketolutarate
citrusol
dextro-cyclodized(tm) akg(tm)
micronized akg
micronized alpha-ketoglutarate
micronized alpha keto glutaric acid
micronized alpha-ketogluterate
Synopsis of Alpha-Ketoglutarate
History
Alpha-Ketoglutarate (AKG) is a naturally occurring compound that plays a pivotal role in the Krebs cycle, an essential energy-producing process in the body. Historically, AKG has been recognized for its contributions to health and wellness, with its medicinal use tracing back to the mid-20th century when researchers began exploring its potential in clinical and nutritional settings. Early studies highlighted its ability to support ammonia detoxification and aid in the synthesis of amino acids, which are crucial for muscle recovery and overall vitality.
In traditional remedies, AKG was often incorporated to address fatigue, enhance physical performance, and support convalescence after illness. Its capacity to promote cellular energy and metabolic efficiency made it a valuable supplement for individuals recovering from surgery or trauma, and it was sometimes used to bolster immune function in those with compromised health.
AKG has also found its place in herbal combinations, synergizing with botanicals such as ashwagandha, ginseng, and spirulina. These combinations are designed to maximize energy, endurance, and stress resilience. By pairing AKG with adaptogenic herbs, practitioners sought to amplify the restorative effects on the body, particularly in the context of age-related decline and chronic fatigue. This holistic approach underscores AKG’s versatility and its positive contributions to health, from athletic performance to overall vitality. Today, alpha-ketoglutarate continues to be celebrated for its support of cellular metabolism, detoxification, and its role in promoting a sense of well-being within nutritional products and herbal formulas alike.
Traditional and scientific validation
Alpha-Ketoglutarate (AKG) is a key intermediate in the Krebs cycle, which plays a fundamental role in cellular energy production. Historically, AKG has garnered interest in the nutritional and sports supplement industries for its potential to enhance athletic performance, support muscle recovery, and promote overall health. It has also been explored in medical contexts, such as in the management of kidney disease and as a nitrogen scavenger in patients with hyperammonemia.
Scientific studies on AKG supplementation in humans have yielded promising, though sometimes inconclusive, results. Some clinical trials suggest that AKG, often combined with amino acids like L-arginine, may help in reducing protein catabolism and preserving muscle mass, particularly in elderly individuals or patients experiencing muscle wasting. Research has also indicated potential benefits in wound healing and gut health, especially in critically ill or post-surgical patients.
In the realm of sports and exercise, some evidence points to AKG’s role in reducing muscle fatigue and enhancing recovery, though these effects have not been universally proven in large-scale, long-term studies. Animal studies have provided further support for AKG’s antioxidant properties and its involvement in modulating immune responses.
While there is a growing body of scientific literature supporting the potential benefits of alpha-ketoglutarate as a nutritional ingredient, more well-designed clinical trials are needed to confirm its efficacy and safety in various populations. Nonetheless, AKG remains a promising compound with diverse applications in health and nutrition.
Alpha-Ketoglutarate is used for these health conditions
Aging (prevention) (Scientific)
Athletic and Exercise Aids (Scientific)
Body Building (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Chemotherapy (reducing side effects) (Scientific)
Convalescence (Scientific)
Energy (lack of) (Scientific)
Exercise (Scientific)
Fatigue (Scientific)
Fatty Liver Disease (Scientific)
Free Radical Damage (Scientific)
Hepatitis (Scientific)
Inflammation (Scientific)
Liver Detoxification (Scientific)
Wounds and Sores (Scientific)
Alpha-Ketoglutarate is used to support these body systems
Gastrointestinal Tract (Scientific)
Hepatic System (Scientific)
Immune System (Scientific)
Intestinal System (Scientific)
Liver (Scientific)
Mitochondria (Scientific)
Muscles (Scientific)