Bitter orange
Other names
advantra z
advantra-z
advantraz
advantraz bitter orange
advantra z bitter orange (citrus aurantium) extract
advantraz bitter orange (citrus aurantium) fruit extract
advantra z bitter orange extract
advantra-z bitter orange extract
advantra-z bitter orange fruit extract
advantra z citrus aurantium
advantra-z citrus aurantium
advantra z (citrus aurantium) extract
advantra z citrus aurantium extract
advantra z citrus aurantium fruit extract
advantra z (citrus aurantium) (unripe fruit) extract
advantra z(r)
advantra-z(r) 30%
advantra z(r) bitter orange
advantra z(r) bitter orange (citrus aurantium) extract
advantraz(r) bitter orange (citrus aurantium) fruit (synephrine) extract
advantra z(r) bitter orange extract
advantra z(r) citrus aurantium
advantra z(r) citrus aurantium fruit extract
advantra-z(r) (citrus aurantium) (unripe fruit) ethanolic/aqueous extract
advantra z(r) fruit extract
aurantii nobilis pericarpium
aurantium
bigarade oranges
bitter orange
bitter orange 99% naringin
bitter orange (citrus aurantiuim) extract
bitter orange (citrus aurantium) extract
bitter orange (citrus aurantium) (fruit) extract
bitter orange (citrus aurantium) fruit extract
bitter orange citrus aurantium (fruit) extract
bitter orange (citrus aurantium) powder
bitter orange (citrus aurantium) (whole fruit) extract
bitter orange (citrus x aurantium) (fruit) extract
bitter orange essence
bitter orange essential oil
bitter orange essential oil extract
bitter orange ext
bitter orange extract
bitter orange fruit
bitter orange (fruit) extract
bitter orange fruit extract
bitter orange fruit extract powder
bitter orange fruit extract, powder
bitter orange fruit peel extract
bitter orange fruit powder
bitter orange nearly mature fruit extract
bitter orange oil
bitter orange peel essence
bitter orange peel essential oil
bitter orange peel essential oil extract
bitter orange peel extract
bitter orange peel extract, dry
bitter orange powder
bitter orange, powder
bitter orange whole fruit extract
bitter orange young fruit extract
c. arurantifolia
certified organic orange (citrus aurantium) peel extract
certified organic orange extract
certified organic zhi shi (citrus x aurantium) dried immature fruit liquid extract
certified organic zhi shi extract
citrus
citrus auranthium
citrus aurantifolia
(citrus) aurantium
citrus aurantium
citrus aurantium 60% extract
citrus aurantium 6% extract
citrus aurantium (citrus aurantium) fruit extract
citrus aurantium (citrus aurantium) unripen fruit extract
citrus aurantium complex
citrus aurantium concentrate, powder
citrus aurantium dulcis peel extract
citrus aurantium extract
citrus aurantium extract complex
citrus aurantium extract powder
citrus aurantium (fruit) ext
citrus aurantium (fruit) extract
citrus aurantium fruit extract
citrus aurantium fruit extract, modified
citrus aurantium fruit extract, powder
citrus aurantium fruit- immature extract
citrus aurantium fruit-immature extract
citrus aurantium (fruit peel) extract
citrus aurantium fruit, peel extract
citrus aurantium fruit powder
citrus aurantium inner peel extract
citrus aurantium l.
citrus aurantium p.e.
citrus aurantium peel ext.
citrus aurantium peel extract
citrus aurantium peel extract, dry
citrus aurantium powder
citrus aurantium, powder
citrus aurantium seed extract
citrus aurantium unripe fruit extract
citrus aurantium var. bergamia fruit extract
citrus aurantium whole fruit extract
citrus bioflavonoid complex
citrus (citrus aurantium) peel extract
citrus (citrus aurantium) skin extract
citrus viride
citrus x aurantium fruit extract, dry
citrus x aurantium peel extract, dry
essence of organic orange (peel) oil
extract of citrus aurantium
fortified bitter orange
fructus aurantia immaturi
immature bitter orange
kinetiq
natural citrus sweetener
neroli orange essence
octopalean
orange
orange essential oil extract
orange extract
orange juice powder
orange peel extract
orange peel tincture
orange powder
orange solid
organic bitter orange
organic bitter orange extract
organic bitter orange (fruit) extract
pericarpium trichosanthes
seville orange (citrus aurantium) extract bioflavonoids
seville orange fruit extract
sour orange 30% extract
sour orange extract
sour orange fruit extract
super synephrine {beta}-3 activator
wild orange (citrus aurantium dulcis) peel oil
young bitter orange
young bitter orange fruit extract
young bitter orange fruit extract concentrate
zhi shi
zhi shi (citrus aurantium)
zhi shi immature fruit extract, dry
Synopsis
History
Bitter orange (Citrus aurantium) has a long and distinguished history in traditional medicine across numerous cultures. Originating in Southeast Asia and spreading to the Mediterranean and beyond, its fruit, peel, and extracts have been valued for centuries. In ancient Chinese and Ayurvedic medicine, bitter orange was used to help with digestive issues, relieve nausea, and stimulate appetite. Throughout the Middle Ages in Europe, it was incorporated into remedies for chest congestion, insomnia, and headaches.
One of the most celebrated uses of bitter orange is in the form of its dried peel, known as chen pi in Traditional Chinese Medicine (TCM). Here, it is utilized to regulate qi (energy), address digestive discomfort, and support the respiratory system. Similarly, folk medicine practitioners in the Mediterranean region have used bitter orange for centuries to calm nerves and promote healthy digestion.
In modern herbalism, bitter orange is often combined with other botanicals to enhance its efficacy. For example, it is paired with ginger, licorice, or cinnamon to support gastrointestinal health and with green tea or guarana in energy and weight management blends. Its natural compounds, including synephrine, are believed to gently stimulate metabolism and promote thermogenesis.
Bitter orange’s versatility and synergy with other herbs have made it a staple in numerous traditional and contemporary remedies. Its enduring reputation as a digestive, respiratory, and metabolic support agent underscores its valuable contributions to natural health practices worldwide.
Traditional and scientific validation
Bitter orange (Citrus aurantium) has a long history of use in traditional medicine, particularly in China and the Mediterranean region, where it has been valued for its purported digestive, stimulant, and appetite-suppressing effects. The fruit, peel, and extract have been incorporated into dietary supplements, especially those aimed at weight management and energy enhancement.
Scientifically, bitter orange contains several bioactive compounds, most notably synephrine, which is structurally similar to ephedrine. This has led to its use as a common alternative to ephedra in nutritional products following ephedra’s restriction. Some clinical studies suggest that bitter orange extract may modestly increase metabolic rate and promote mild weight loss when combined with diet and exercise. For example, a review published in the International Journal of Medical Sciences (2012) found that bitter orange, particularly its synephrine component, could have a positive impact on fat oxidation and energy expenditure in healthy adults.
Additionally, bitter orange has demonstrated antioxidant and anti-inflammatory properties in laboratory settings, hinting at broader health benefits. However, while moderate use in healthy individuals appears safe, more research is needed to establish its long-term efficacy and safety, especially concerning cardiovascular health, as synephrine may influence blood pressure and heart rate.
Overall, bitter orange remains a promising natural ingredient with a rich history and emerging scientific support for certain uses, but further high-quality clinical trials are needed to fully validate its effects and guide safe supplementation.
Uses: Health Conditions
Appetite (deficient) (Traditional)
Athletic and Exercise Aids (Scientific)
Constipation (adults) (Traditional)
Digestion (poor) (Traditional)
Fat Metabolism (poor) (Scientific)
Fatigue (Traditional)
Gas and Bloating (Traditional)
Indigestion (Traditional)
Inflammation (Traditional)
Metabolic Syndrome (Scientific)
Nausea and Vomiting (Traditional)
Weight Loss (Scientific)
Energy (lack of) (Scientific)
Stress (Traditional)
Body Systems
Circulatory System (Traditional)
Digestive System (Traditional)
Gastrointestinal Tract (Traditional)
Intestinal System (Traditional)
Lungs (Traditional)
Respiratory System (Traditional)
Stomach (Traditional)