Citrulline
Other names for Citrulline
2-amino-5-(carbamoylamino) pentanoic acid
citrulline
citrulline hydrochloride
citrulline, micronized
citrulline nitrate
citrulline peptides
kyowa quality
kyowa quality l-citrulline
l-citruline
l-citrulline
l-citrulline extract
l-citrulline, fermented
l-citrulline hcl
l-citrulline hydrochloride
l-citrulline, micronized
l-citrulline monohydrate
l-citrulline nitrate
l-citrulline peptides
l-citrulline, powder
micronized l-citrulline
nitramax
no3-t
pepform
pepform(r) citrulline peptides
Synopsis of Citrulline
History
Citrulline, a naturally occurring amino acid, derives its name from the Latin word for watermelon, Citrullus, reflecting its initial discovery in watermelon juice in the early 20th century. However, the medicinal use of watermelon and other citrulline-containing plants predates its scientific isolation. In traditional folk medicine, watermelon pulp and seeds were consumed to support kidney health, promote diuresis, and alleviate fatigue—benefits now attributed in part to citrulline’s unique metabolic properties. Additionally, certain herbal remedies in Asia and Africa combined watermelon with other botanicals to address blood pressure and improve circulation, harnessing the vasodilating effects that modern science associates with citrulline’s role in nitric oxide production.
In contemporary herbal medicine, citrulline is often incorporated into synergistic blends with herbs such as ginseng, hawthorn, and beetroot. These combinations are celebrated for their ability to enhance physical endurance, cardiovascular health, and overall vitality. Citrulline’s capacity to promote blood flow and reduce muscle fatigue makes it a valued component in herbal tonics aimed at boosting athletic performance and recovery. Its mild diuretic effect also complements other herbs in supporting detoxification and kidney function. Over time, citrulline has emerged as a powerful, naturally derived ingredient, revered both in isolation and as part of traditional and modern herbal remedies, continuing its legacy as a positive force for well-being and holistic health.
Traditional and scientific validation
Citrulline is a naturally occurring amino acid first isolated from watermelon in the early 20th century. Its name is derived from "Citrullus," the Latin word for watermelon. Historically, citrulline garnered scientific interest due to its role in the urea cycle, where it facilitates the removal of ammonia from the body. In recent decades, citrulline—particularly in the form of L-citrulline and citrulline malate—has gained popularity as a dietary supplement, especially among athletes and individuals seeking to support cardiovascular health.
Modern research suggests that citrulline supplementation may have several benefits. Notably, it serves as a precursor to L-arginine, another amino acid involved in nitric oxide production, which helps promote vasodilation and improved blood flow. Several clinical studies have investigated these effects. For instance, some trials have shown that citrulline supplementation can enhance exercise performance, delay muscle fatigue, and reduce muscle soreness, especially during high-intensity or endurance-based activities. Additionally, limited studies have indicated potential benefits for cardiovascular health, such as modest reductions in blood pressure and improved endothelial function.
Despite promising findings, it is important to note that research on citrulline's efficacy is still evolving. While some results are encouraging, larger and more rigorous clinical trials are needed to confirm its benefits and establish optimal dosing guidelines. Nonetheless, citrulline remains a well-tolerated and safe supplement for most individuals, and its role in supporting exercise performance and vascular health continues to be an exciting area of scientific exploration.
Citrulline is used for these health conditions
Angina (Scientific)
Athletic and Exercise Aids (Scientific)
Cardiovascular Disease (Scientific)
Circulation (poor) (Scientific)
Congestive Heart Failure (Scientific)
Erectile Dysfunction (Scientific)
Exercise (Scientific)
Fatigue (Scientific)
Hypertension (Scientific)
Sex Drive (low) (Scientific)
Citrulline is used to support these body systems
Arteries (Scientific)
Blood (Scientific)
Circulatory System (Scientific)
Heart (Scientific)
Male Reproductive System (Scientific)
Muscles (Scientific)