Citrulline aspartate
Synopsis of Citrulline aspartate
History
Citrulline aspartate is a compound formed by combining the amino acids citrulline and aspartic acid. Discovered in the mid-20th century, citrulline aspartate quickly gained attention in Europe, particularly France, for its medicinal applications. Historically, it has been used as a remedy to combat fatigue, boost energy, and support recovery from physical exertion. In clinical practice, physicians have recommended citrulline aspartate to patients suffering from asthenia (generalized weakness), convalescence, and liver dysfunction due to its beneficial effects on ammonia detoxification and the urea cycle.
This compound’s popularity surged in the 1960s and 1970s, with reports highlighting its ability to enhance athletic performance, speed muscle recovery, and alleviate symptoms of chronic fatigue. Citrulline aspartate was also sometimes prescribed to support cardiovascular health, as it assists in nitric oxide production, which can improve blood flow and vascular function. Its safety profile and tolerability further contributed to its positive reputation among healthcare professionals.
In the context of herbal combinations, citrulline aspartate is often included in formulations with adaptogenic herbs like ginseng, rhodiola, or schisandra. These blends aim to amplify energy, endurance, and mental clarity. The synergistic effect of citrulline aspartate with herbal components supports both physical and cognitive vitality, making it a valued ingredient in modern nutraceuticals and traditional remedies alike. Overall, citrulline aspartate stands out for its remarkable contributions to health, wellness, and holistic medicine.
Traditional and scientific validation
Citrulline aspartate is a compound formed by combining the amino acids citrulline and aspartic acid. Its use in nutritional products dates back to the mid-20th century, particularly in Europe, where it was initially marketed for its potential to combat fatigue and enhance physical performance. The rationale behind its use stems from citrulline’s role in the urea cycle, which helps remove ammonia—a byproduct of intense exercise—from the body, and aspartate’s involvement in cellular energy production.
Several clinical studies have explored the benefits of citrulline aspartate supplementation, primarily in athletic and fatigue-related contexts. Early research found that it could reduce the sensation of fatigue and improve aerobic performance in athletes and individuals experiencing physical exhaustion. More recent trials suggest that citrulline aspartate may enhance exercise capacity and delay the onset of muscle fatigue by increasing the rate of ammonia clearance and supporting ATP (energy) production. Additionally, there is evidence that citrulline supplementation may improve blood flow by increasing nitric oxide production, which can further benefit exercise performance and recovery.
While citrulline aspartate has shown promise, especially in reducing exercise-induced fatigue and supporting endurance, more rigorous, large-scale clinical studies are needed to confirm its efficacy and understand its mechanisms fully. Nonetheless, its favorable safety profile and positive outcomes in initial studies make it a valuable ingredient in sports and nutritional formulations, supporting overall energy metabolism and recovery in active individuals.
Citrulline aspartate is used for these health conditions
Athletic and Exercise Aids (Scientific)
Body Building (Scientific)
Cardiovascular Disease (Scientific)
Circulation (poor) (Scientific)
Energy (lack of) (Scientific)
Fatigue (Scientific)
Muscle Tone (lack of) (Scientific)
Citrulline aspartate is used to support these body systems
Blood (Scientific)
Circulatory System (Scientific)
Muscles (Scientific)