Dihydromyricetin
Synopsis of Dihydromyricetin
History
Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound primarily extracted from the Japanese raisin tree (Hovenia dulcis) and several other plants. Its use in traditional medicine dates back centuries, particularly in East Asia, where it has played a significant role in herbal remedies. Ancient practitioners in China and Japan utilized extracts from the Japanese raisin tree as a hangover remedy and to support liver health, capitalizing on DHM’s remarkable antioxidant and hepatoprotective properties.
Traditionally, DHM-rich decoctions were consumed to alleviate symptoms of alcohol intoxication, bolster the body's natural detoxification processes, and promote recovery after excessive drinking. Folk medicine often praised its ability to clear “damp-heat” from the liver, reduce fatigue, and restore vitality. Over time, such uses have inspired modern research, which confirms DHM’s capacity to modulate alcohol metabolism, protect liver cells, and counteract oxidative stress.
Dihydromyricetin is also commonly found in various herbal combinations. In traditional formulas, it is often paired with herbs like Pueraria lobata (kudzu root) and Schisandra chinensis, which together synergize to support liver function, enhance detoxification, and mitigate the negative effects of alcohol. Such combinations are celebrated for their holistic approach to wellness, maximizing the individual benefits of each component.
Today, dihydromyricetin is recognized as a valuable ingredient in nutritional supplements and functional beverages. Its historical significance and continued use underscore its positive contributions to natural health practices, especially in supporting liver health and recovery from alcohol-related discomfort.
Traditional and scientific validation
Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound extracted primarily from the Japanese raisin tree (Hovenia dulcis). Historically, this herbal ingredient has been utilized in traditional Chinese medicine for centuries, especially for managing alcohol intoxication and supporting liver health. Its longstanding use in East Asian cultures highlights its perceived safety and therapeutic potential.
In recent years, scientific interest in DHM has grown, with several preclinical and clinical studies exploring its effects. Research has indicated that DHM may modulate GABA receptors in the brain, which could help counteract the depressive effects of alcohol on the central nervous system. Animal studies have shown promising results in reducing alcohol-induced intoxication, withdrawal symptoms, and even the risk of alcohol dependency. Additionally, DHM exhibits antioxidant and anti-inflammatory properties, which may contribute to liver protection and general wellness.
Some small-scale human studies and anecdotal reports suggest DHM may lessen hangover symptoms and support cognitive function after alcohol consumption. However, large, well-controlled clinical trials in humans are still limited, and more research is needed to robustly validate these effects. Nevertheless, its favorable safety profile and traditional use support its inclusion in nutritional products aimed at supporting liver function and alcohol metabolism. As scientific understanding evolves, DHM's contributions to health and wellness continue to be promising, warranting further exploration in future research.
Dihydromyricetin is used for these health conditions
Alcoholism (Scientific)
Fatty Liver Disease (Scientific)
Hangover (Scientific)
Inflammation (Scientific)
Liver Detoxification (Scientific)
Dihydromyricetin is used to support these body systems
Brain (Scientific)
GABA (Scientific)
Hepatic System (Scientific)
Liver (Scientific)