Diosmetin
Other names for Diosmetin
3\',5,7-trihydroxy-4\'-methoxyflavone
3,5,7 trihydroxy-4-methoxyflavone 92%
3,5,7-trihydroxy-4-methoxyflavone 92%
5,7-dihydroxy-4\'-methoxyflavone
diosmetin
diosmetin 0.1%
diosmetin-7-o-glucoside
diosmetin-7-o-glucoside 0.44%
diosmin
naturally occurring diosmetin
naturally occurring diosmetin-7-o-glucoside
Synopsis of Diosmetin
History
Diosmetin is a naturally occurring flavonoid, primarily found in citrus fruits, that has a long-standing history in traditional medicine. Historically, diosmetin and its glycoside form, diosmin, have been utilized for their reputed ability to support vascular health and promote healthy circulation. Ancient Greek and Roman herbalists valued extracts from plants rich in diosmetin for addressing a range of ailments, most notably those related to venous insufficiency, such as swelling, varicose veins, and hemorrhoids.
In folk remedies, diosmetin-containing plants were often brewed into teas or prepared as topical applications to alleviate symptoms of inflammation and improve capillary strength. The positive effects on blood vessels and anti-inflammatory properties made diosmetin a staple in natural approaches to maintaining cardiovascular wellness. Over time, its use expanded across Europe and into traditional Asian medicine, where it was combined with other botanicals such as horse chestnut and butcher’s broom to synergistically enhance vascular support and reduce discomfort associated with poor circulation.
In modern herbal formulations, diosmetin is frequently included alongside hesperidin, rutin, and vitamin C, leveraging their collective antioxidant and anti-inflammatory potential. These combinations are praised for supporting healthy veins, reducing oxidative stress, and promoting overall wellness. The enduring legacy and modern validation of diosmetin’s benefits underscore its valuable contributions to natural health, demonstrating how traditional remedies can inform and complement contemporary approaches to wellness.
Traditional and scientific validation
Diosmetin is a naturally occurring flavonoid, primarily found in citrus fruits and derived from the hydrolysis of diosmin. Historically, diosmetin and related compounds have been utilized in traditional medicine for their potential benefits in supporting vascular health, particularly in addressing chronic venous insufficiency and hemorrhoidal conditions. The interest in diosmetin as a nutritional ingredient is largely based on its antioxidant, anti-inflammatory, and vasoprotective properties.
Scientific validation for the use of diosmetin comes from several preclinical and clinical studies, although most research has focused on its glycosylated form, diosmin. Studies have suggested that diosmetin exhibits free radical scavenging activity and may help to strengthen capillary walls, reduce inflammation, and improve microcirculation. Some clinical trials involving diosmin (which is metabolized into diosmetin in the body) have demonstrated benefits in reducing symptoms such as leg swelling, pain, and heaviness in individuals with venous insufficiency. Additionally, in vitro and animal models have indicated that diosmetin may modulate inflammatory pathways and protect endothelial function.
Despite these promising findings, it is important to note that direct clinical evidence specifically for diosmetin remains limited. Most available human studies have investigated diosmin rather than diosmetin alone. Therefore, while diosmetin appears to contribute positively to vascular health and antioxidant defense, further well-designed clinical trials are needed to confirm and clarify its efficacy and safety profile as a standalone ingredient. Nonetheless, diosmetin continues to attract attention as a valuable component in nutritional products aimed at supporting circulatory and overall vascular well-being.
Diosmetin is used for these health conditions
Cancer (natural therapy for) (Scientific)
Cancer (prevention) (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Cardiovascular Disease (Scientific)
Circulation (poor) (Scientific)
Diabetes (Scientific)
Free Radical Damage (Scientific)
Inflammation (Scientific)
Osteoporosis (Scientific)
Diosmetin is used to support these body systems
Arteries (Scientific)
Blood (Scientific)
Capillaries (Scientific)
Circulatory System (Scientific)
Veins (Scientific)