Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Synopsis
History
Dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide, commonly known as one of the key alkamides found in Echinacea species, has a rich history of use in traditional and indigenous medicine, particularly among Native American communities. For centuries, preparations from the roots and aerial parts of Echinacea—notably Echinacea angustifolia and Echinacea purpurea—have been prized for their immune-enhancing and anti-inflammatory properties. These remedies were traditionally applied to wounds, bites, and infections, as well as consumed to alleviate symptoms of colds, sore throats, and respiratory infections.
The alkamide Dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide is believed to contribute significantly to these benefits, supporting the body's natural defenses by modulating immune cell activity and reducing inflammation. Modern research has validated many of these traditional uses, highlighting its role in stimulating macrophage activity and promoting overall immune health.
In herbal medicine, this compound is seldom used in isolation but rather as part of synergistic blends, most commonly in combination with other Echinacea constituents, as well as herbs like goldenseal (Hydrastis canadensis), elderberry (Sambucus nigra), and astragalus (Astragalus membranaceus). Such combinations are popular for bolstering immune function, shortening the duration of upper respiratory infections, and enhancing the body’s resilience to stress and pathogens. Overall, Dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide stands out as a valuable natural compound that continues to play a vital role in both traditional and modern herbal remedies.
Traditional and scientific validation
Dodeca-2E,4E,8Z,10Z/tetraenoic acid isobutylamide is a naturally occurring alkamide primarily found in Echinacea species, particularly Echinacea angustifolia and Echinacea purpurea. Historically, Echinacea extracts have been widely utilized in traditional herbal medicine, especially by Native Americans, for their purported immunomodulatory and anti-inflammatory properties. The alkamides, including dodeca-2E,4E,8Z,10Z/tetraenoic acid isobutylamide, are considered key bioactive components responsible for many of these health-promoting effects.
Scientific investigations have focused on the potential benefits of Echinacea alkamides in supporting immune function. Several in vitro and animal studies suggest that these compounds can modulate cytokine production, influence macrophage activity, and interact with the endocannabinoid system, which may contribute to their observed effects on immune response and inflammation. Some clinical studies involving Echinacea preparations, which contain this and other alkamides, have reported modest reductions in the duration and severity of upper respiratory tract infections, although results are mixed and often limited by study design variations.
Despite promising findings from laboratory and preliminary clinical research, the specific role of dodeca-2E,4E,8Z,10Z/tetraenoic acid isobutylamide in human health remains to be fully elucidated. More rigorous, targeted clinical trials are needed to substantiate its efficacy and safety as a stand-alone nutraceutical ingredient. Nonetheless, current evidence supports its contribution to the immunomodulatory effects attributed to Echinacea, making it a valuable component in nutritional formulations aimed at supporting immune health.
Uses: Health Conditions
Pain (general remedies for) (Traditional)
Inflammation (Scientific)
Stress (Traditional)
Circulation (poor) (Scientific)
Colds (general) (Traditional)
Colds (prevention) (Traditional)
Sore Throat (Traditional)
Body Systems
Blood (Traditional)
Immune System (Traditional)
Respiratory System (Traditional)