Glycyrrhizin
Other names
25% glycyrrhizin
3% glycyrrhizin
glcyrrhizin
glycryyhizin
glycyrrhizin
glycyrrhizin complex
glycyrrhizin content
glycyrrhizine
glycyrrhizin extract
glycyrrhizinic acid
glycyrrhiznic acid
monoammoniated glycyrrhizin
mono ammonium glycyrrhizinate
monoammonium glycyrrhizinate
standardized to provide 60 mg glycyrrhizin
Synopsis
History
Glycyrrhizin, a key bioactive compound derived from the root of Glycyrrhiza glabra (commonly known as licorice), has been celebrated for centuries in traditional medicine systems across the globe. Its use dates back to ancient Egypt, China, and Greece, where it was esteemed not only as a sweetener but also as a potent remedy for a wide spectrum of ailments. In Traditional Chinese Medicine (TCM), licorice root—rich in glycyrrhizin—was often called the “great harmonizer.” It was included in numerous herbal formulas to boost the efficacy of other herbs, moderate harsh properties, and support overall wellness. Glycyrrhizin was commonly used to soothe sore throats, relieve coughs, and support digestive health.
In Ayurveda, licorice root was prized for its rejuvenating and anti-inflammatory properties, often employed to treat respiratory conditions, gastric ulcers, and as a tonic for vitality. Across the Mediterranean and Middle Eastern traditions, infusions of licorice root were utilized for their expectorant and demulcent effects, providing relief from bronchial discomfort and promoting mucosal healing.
Modern herbalism continues to value glycyrrhizin for its adaptogenic, anti-inflammatory, and antiviral benefits. It is frequently combined with herbs such as ginger, ginseng, and astragalus in both traditional and contemporary formulas, enhancing immune function, reducing stress, and supporting adrenal health. Glycyrrhizin’s ability to harmonize herbal blends and its multifaceted health benefits underscore its ongoing positive contributions to natural medicine and nutritional products. Used responsibly, it remains a cornerstone of holistic wellness practices around the world.
Traditional and scientific validation
Glycyrrhizin is a major bioactive compound found in the root of Glycyrrhiza glabra, commonly known as licorice. Historically, licorice root has been valued in traditional medicine systems, such as Traditional Chinese Medicine and Ayurveda, for its purported effects on digestive health, respiratory conditions, and as a general tonic. The use of glycyrrhizin-rich extracts dates back thousands of years, with records showing its application for soothing sore throats, ulcers, and coughs.
Modern scientific investigations have explored glycyrrhizin's diverse pharmacological properties, including its anti-inflammatory, antiviral, and hepatoprotective effects. Several clinical studies have evaluated its efficacy, particularly in the context of liver health. For instance, glycyrrhizin has been studied in the management of chronic hepatitis, with some trials suggesting improvements in liver function markers and a reduction in liver inflammation. Its antiviral properties have also been highlighted in laboratory studies, where glycyrrhizin demonstrated inhibitory effects against viruses like hepatitis C and even SARS-associated coronavirus.
Despite these promising findings, the clinical evidence supporting all of glycyrrhizin’s health claims remains incomplete. Some studies indicate potential benefits, while others call for larger, more rigorous trials to confirm its safety and efficacy. Nevertheless, glycyrrhizin continues to be an important ingredient in nutritional and herbal products, valued for its historical usage and emerging scientific support. As research progresses, glycyrrhizin may reveal further contributions to health and wellness, though responsible use and ongoing investigation remain essential.
Uses: Health Conditions
Autoimmune Disorders (Scientific)
Bronchitis (Scientific)
Cirrhosis of the Liver (Scientific)
Cold Sores (Scientific)
Colds (antiviral) (Scientific)
Colds (general) (Traditional)
Cough (general) (Traditional)
Cough (spastic) (Traditional)
Gastritis (Scientific)
Hepatitis (Scientific)
Herpes (Scientific)
Inflammation (Scientific)
Influenza (Scientific)
Liver Detoxification (Scientific)
Oral Surgery (Scientific)
Psoriasis (Scientific)
Rhinitis (Scientific)
Ulcers (Scientific)
Wounds and Sores (Scientific)
Body Systems
Adrenal Cortex (Scientific)
Adrenal Glands (Scientific)
Cortisol (Scientific)
Digestive System (Traditional)
Gastrointestinal Tract (Scientific)
Glandular System (Traditional)
Immune System (Scientific)
Intestinal System (Scientific)
Liver (Scientific)
Lungs (Scientific)
Mucus Membranes (Scientific)
Respiratory System (Scientific)
Spleen (Traditional)
Stomach (Scientific)
Bronchials (Traditional)
Hepatic System (Traditional)
Small Intestines (Traditional)