Guggulsterone
Other names for Guggulsterone
7.5% guggulsterone
e&g guggulsterones
e-guggulsterone
e-guggulsterone isomer
e {guggulsterones}
e&z gugglesterones
e & z guggulsterones
e&z guggulsterones
guggelsterones
gugglesterone e & z
gugglesterones
guggul ez100
guggulipid glycerite liquid extract
guggulsterone
guggulsterone e and z (commiphora wightii) 5:1 extract
guggulsterone extract
guggulsterone gum extract
guggulsterones
guggulsterones 2.5%
guggulsterones e&z
guggulsterones note: 25 mg
guggulsterones, z & e
guggulsterone tree extract
gugulsterones
standardized to 10% total z & e guggalsterones
synthetic 99% guggelsterones e&z 1:1
synthetic 99% guggulsterones z&e 1:1
synthetic guggulsterones z&e 1:1
yielding 40mg guggulsterones
z & e guggulsterones
z&e guggulsterones
z-guggulsterone
z-guggulsterone isomer
z {guggulsterones}
z guggulsterones
Synopsis of Guggulsterone
History
Guggulsterone is a bioactive compound derived from the resin of the Commiphora mukul tree, commonly known as guggul. This plant has a rich history in traditional Ayurvedic medicine, dating back over two thousand years. Guggul resin was highly valued in ancient remedies for its purported ability to balance the body's doshas and promote overall well-being. It was especially esteemed for addressing ailments such as obesity, arthritis, and lipid disorders. Historical texts describe its use in formulas aimed at purifying the blood, alleviating joint pain, and supporting cardiovascular health.
One of guggulsterone's most celebrated applications was in managing "Medoroga," a condition akin to modern-day metabolic syndrome. Practitioners would often prescribe guggul as a core ingredient in various herbal decoctions and powders to support healthy cholesterol and triglyceride levels. Its anti-inflammatory and antioxidant properties contributed to its popularity for treating skin diseases and inflammatory conditions.
Guggulsterone is rarely used in isolation; it typically forms part of powerful herbal combinations. For instance, the renowned Ayurvedic blend "Triphala Guggul" combines guggul with triphala (a mix of three fruits), amplifying its detoxifying and rejuvenating effects. Similarly, "Yograj Guggul" incorporates a synergy of herbs and guggul to support joint health and mobility. These formulations not only enhance guggul’s therapeutic effects but also broaden its range of benefits, helping to harmonize the body’s natural processes.
Overall, guggulsterone’s enduring use in traditional remedies and its inclusion in synergistic herbal blends underscore its valuable contributions to natural health and wellness.
Traditional and scientific validation
Guggulsterone is a plant sterol derived from the resin of the Commiphora mukul tree, commonly known as guggul, which has been used in Ayurvedic medicine for centuries. Traditionally, guggul extracts were valued for their purported benefits in managing cholesterol, supporting weight loss, and promoting overall metabolic health. The historical use of guggul in Indian medicine provides a strong foundation for its inclusion in modern nutritional products.
Scientific interest in guggulsterone surged following studies suggesting its potential to modulate lipid metabolism. Early research indicated that guggulsterone acts as an antagonist to the farnesoid X receptor (FXR), a nuclear hormone receptor involved in the regulation of cholesterol and bile acid metabolism. Some clinical trials from India have reported that guggul extracts may reduce total cholesterol and low-density lipoprotein (LDL) cholesterol levels, supporting its traditional use for cardiovascular health. For instance, a notable study published in the Journal of the Association of Physicians of India reported significant cholesterol-lowering effects in participants taking guggulipid supplements.
However, results from Western clinical studies have been mixed, with some failing to replicate the cholesterol-lowering results observed in Indian populations. The variability may stem from differences in extract standardization, diet, or genetic factors. While guggulsterone continues to be researched for its anti-inflammatory and metabolic effects, current scientific evidence is not yet conclusive. Nevertheless, its long-standing use in traditional medicine and promising early research underscore its potential as a natural ingredient in nutritional products. More robust, large-scale clinical trials are needed to validate its health benefits fully.
Guggulsterone is used for these health conditions
Cholesterol (high) (Traditional)
Diabetes (Traditional)
Inflammation (Traditional)
Metabolic Syndrome (Scientific)
Triglycerides (high) (Traditional)
Guggulsterone is used to support these body systems
Blood (Traditional)
Circulatory System (Traditional)
Digestive System (Traditional)
Gall Bladder (Traditional)
Glandular System (Traditional)
Heart (Traditional)
Hepatic System (Traditional)
Joints (Traditional)