Neohesperidin
Synopsis of Neohesperidin
History
Neohesperidin is a naturally occurring flavonoid glycoside predominantly found in citrus fruits such as bitter oranges. Historically, this compound and its parent plant sources have held a valuable place in traditional medicine, especially in regions surrounding the Mediterranean and Asia. Folk remedies have long utilized citrus peels—rich in neohesperidin—for their purported ability to aid digestion, relieve cough, and reduce inflammation. These peels were often brewed into teas or incorporated into tinctures to harness their beneficial effects. In traditional Chinese medicine, bitter orange was commonly prescribed to address gastrointestinal discomfort, support respiratory health, and stimulate appetite.
Neohesperidin's medicinal potential is largely attributed to its antioxidant, anti-inflammatory, and antimicrobial properties. Over centuries, herbalists combined neohesperidin-containing citrus extracts with other botanicals such as licorice root, ginger, and ginseng, creating synergistic blends tailored to boost immunity, ease sore throats, and promote overall vitality. These combinations were not only valued for their efficacy but also for enhancing the palatability of herbal remedies, as neohesperidin and its derivative, neohesperidin dihydrochalcone (NHDC), impart a pleasant sweetness to otherwise bitter formulations.
Modern nutritional science continues to recognize neohesperidin's positive contributions. It is now a favored ingredient in nutritional supplements and functional foods, supporting cardiovascular health, metabolic balance, and immune function. Its historical use in herbal combinations serves as a testament to its versatility, efficacy, and enduring value in promoting human wellness across diverse cultures.
Traditional and scientific validation
Neohesperidin is a flavonoid glycoside naturally found in citrus fruits, particularly in bitter oranges. Historically, extracts containing neohesperidin have been used in traditional remedies for their purported health benefits, including support for digestion and immune health. In the modern era, neohesperidin and its derivatives, such as neohesperidin dihydrochalcone (NHDC), have gained attention as potent sweeteners and bioactive compounds in nutritional products.
Scientific research on neohesperidin has highlighted its antioxidant, anti-inflammatory, and potential metabolic benefits. In vitro and animal studies have demonstrated that neohesperidin may help neutralize free radicals and modulate inflammatory pathways, suggesting a protective role against oxidative stress-related diseases. Some preclinical studies have also explored its potential to regulate lipid and glucose metabolism, indicating possible benefits for cardiovascular and metabolic health.
As a food ingredient, neohesperidin dihydrochalcone (NHDC) is valued for its intense sweetness and favorable safety profile, having been approved as a sweetener in various regions. Human clinical studies on neohesperidin itself remain limited, but available evidence points to its safety and possible health-promoting properties when included in a balanced diet. While comprehensive clinical validation is still needed to confirm its efficacy for specific health claims, neohesperidin’s antioxidant and sweetening properties make it a valuable addition to nutritional products. Ongoing research continues to explore its full potential, with early findings supporting its positive contributions to health and nutrition.
Neohesperidin is used for these health conditions
Diabetes (Scientific)