Nicotinamide Adenine Dinucleotide
Other names for Nicotinamide Adenine Dinucleotide
beta-nicotinamide adenine dinucleotide
b-nicotinamide adenine dinucleotide
co-e1 nadh
co-e1(r) nadh
enada co-e1 nadh
enada nadh
nad
nadh
nad (nicotinamide adenine dinucleotide) trihydrate
nad [nicotinamide adenine dinucleotide] trihydrate
nad trihydrate
naoh
nicotinamide adenine dinucleotide
nicotinamide adenine dinucleotide complex
nicotinamide adenine dinucleotide hydrate
nicotinamide adenine dinucleotide hydride
nicotinamide adenine dinucleotide + hydrogen
nicotinamide adenine dinucleotide, reduced
nicotinamide adenine dinucleotide sodium
panmol nadh
panmol nadhmicro
reduced beta-nicotinamide adenine dinucleotide
Synopsis of Nicotinamide Adenine Dinucleotide
History
Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme present in all living cells, playing a crucial role in cellular energy production and metabolic processes. Historically, NAD+ and its precursors—most notably nicotinamide (a form of vitamin B3)—have been valued for their medicinal properties since the early 20th century. The discovery of vitamin B3’s ability to prevent and treat pellagra, a deficiency disease characterized by dermatitis, diarrhea, and dementia, marked a major milestone in nutritional science. Supplementation with NAD+ precursors has since been recognized for supporting neurological health, reducing fatigue, and promoting skin vitality.
In traditional remedies, nicotinamide-rich foods and herbal infusions were often used to enhance vitality and counteract symptoms of malnutrition or chronic illness. While NAD+ itself is not typically found in herbal preparations, its boosting compounds—like nicotinamide, niacin, and tryptophan—are present in many plants, such as brewer’s yeast, sunflower seeds, and certain medicinal herbs. These ingredients have long been combined with adaptogens and antioxidants in herbal mixtures to enhance energy, resilience, and overall wellness.
Modern research continues to highlight NAD+’s positive contributions, including its role in DNA repair, healthy aging, and cognitive function. Its integration into nutritional products and innovative herbal combinations underscores its enduring value. By supporting fundamental cellular processes, NAD+ stands out as an essential component in both traditional and contemporary approaches to health and wellbeing.
Traditional and scientific validation
Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme found in all living cells, playing a central role in energy metabolism and cellular function. Historically, NAD+ was first discovered in the early 20th century during research into fermentation, and its significance in redox reactions led to the recognition of its fundamental role in biochemistry. In recent years, NAD+ and its precursors—such as nicotinamide riboside and nicotinamide mononucleotide—have garnered attention as nutritional ingredients due to their potential to support health and longevity.
Scientific validation of NAD+ supplementation is an active area of research. Several preclinical studies have demonstrated that boosting NAD+ levels can improve mitochondrial function, enhance DNA repair, and promote healthy aging in animal models. Early-phase human clinical trials suggest that NAD+ precursors are safe and can increase NAD+ concentrations in blood and tissues, with promising indications for metabolic health, neuroprotection, and cardiovascular function. For example, a 2016 study published in Nature Communications showed that supplementation with nicotinamide riboside increased NAD+ levels and improved some markers of cardiovascular health in older adults.
While these findings are encouraging, comprehensive clinical evidence supporting specific health outcomes in humans is still emerging. Larger and longer-term studies are needed to confirm the benefits and fully understand the safety profile of NAD+ supplementation. Nevertheless, the current body of research highlights NAD+'s critical role in cellular health and its promising potential as a nutritional ingredient to support energy metabolism and healthy aging.
Nicotinamide Adenine Dinucleotide is used for these health conditions
Alzheimer's Disease (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Cardiovascular Disease (Scientific)
Fatigue (Scientific)
Inflammation (Scientific)
Memory and Brain Function (Scientific)
Metabolic Syndrome (Scientific)
Multiple Sclerosis (Scientific)
Nerve Damage (Scientific)
Parkinson's Disease (Scientific)
Peripheral Neuropathy (Scientific)
Nicotinamide Adenine Dinucleotide is used to support these body systems
Blood (Scientific)
Brain (Scientific)
Circulatory System (Scientific)
Heart (Scientific)
Immune System (Scientific)
Liver (Scientific)
Mitochondria (Scientific)
Muscles (Scientific)
Nerves (Scientific)
Respiratory System (Scientific)
Skin (Scientific)