Ornithine ketoglutarate
Other names for Ornithine ketoglutarate
l-ornathine alpha-ketoglutarate
l-ornithine akg
l-ornithine-akg
l-ornithine alpha keto glutarate
l-ornithine alpha ketoglutarate
l-ornithine alpha- ketoglutarate
l-ornithine alpha-ketoglutarate
l-ornithine alphaketoglutarate
l-ornithine alpha-ketoglutarate acid
l-ornithine ketoglutarate
okg
ornithine akg
ornithine alpha-ketoglurate
ornithine alpha keto glutarate
ornithine alpha ketoglutarate
ornithine alpha- ketoglutarate
ornithine alpha-ketoglutarate
ornithine alphaketoglutarate
ornithine-{alpha}-ketoglutarate
ornithine-alpha-ketoglutarate
ornithine-alpha-ketogluterate
ornithine ketoglutarate
Synopsis of Ornithine ketoglutarate
History
Ornithine ketoglutarate (OKG) is a compound formed by combining the amino acid ornithine with alpha-ketoglutaric acid, a key molecule in the Krebs cycle. Historically, OKG emerged in the mid-20th century as a promising nutritional and medicinal supplement, especially valued for its role in supporting protein metabolism and tissue repair. It gained considerable attention in clinical nutrition, particularly for patients experiencing muscle wasting, trauma, or surgery, where it was found to promote nitrogen retention and enhance wound healing.
Medicinally, OKG has been widely used to support convalescence and recovery from illnesses that lead to catabolic states, such as burns, infections, and malnutrition. Physicians often recommended it as a remedy to help restore vitality, reduce muscle loss, and accelerate recovery times. Its ability to stimulate growth hormone secretion and modulate immune responses further contributed to its therapeutic appeal.
In the realm of herbal combinations, OKG is sometimes paired with adaptogenic herbs and botanical extracts known for their restorative properties. For example, it may be blended with ginseng, ashwagandha, or astragalus to synergistically enhance stamina, support immune function, and foster overall well-being. These combinations are particularly popular in formulations aimed at athletes, the elderly, or individuals recovering from chronic illness, as they harness both the metabolic benefits of OKG and the holistic effects of traditional herbs.
Overall, ornithine ketoglutarate has made significant contributions to nutritional therapy, providing a scientifically backed option for improving recovery, supporting muscle maintenance, and enhancing the efficacy of herbal remedies. Its safety profile and versatile applications continue to make it a respected ingredient in modern nutritional and herbal medicine.
Traditional and scientific validation
Ornithine ketoglutarate (OKG) is a salt formed from the amino acid ornithine and alpha-ketoglutarate, gaining attention as a nutritional supplement, particularly in clinical nutrition and recovery settings. Historically, OKG was introduced in the 1970s and 1980s as a potential agent for promoting protein synthesis and reducing muscle catabolism, especially in patients experiencing trauma, burns, or surgical recovery. Early studies suggested that OKG supplementation could enhance wound healing, improve nitrogen balance, and support immune function, making it a candidate for inclusion in enteral and parenteral nutrition formulas.
Scientifically, OKG is thought to exert its beneficial effects by providing substrates for the urea cycle and stimulating the secretion of anabolic hormones such as insulin and growth hormone. Several clinical studies, including randomized controlled trials, have investigated its impact. Some have reported that OKG supplementation in hospitalized or critically ill patients can result in improved protein retention, reduced muscle breakdown, and faster recovery. In elderly populations or those with malnutrition, OKG has been associated with better appetite and slight improvements in muscle mass.
However, the overall evidence remains mixed, with some studies failing to demonstrate significant or consistent benefits. While OKG is well-tolerated and shows promise as an adjunct in nutritional therapy, more large-scale, high-quality research is needed to definitively establish its efficacy and optimal use. Nevertheless, its favorable safety profile and potential benefits continue to support its use in specialized nutritional products for vulnerable populations.
Ornithine ketoglutarate is used for these health conditions
Athletic and Exercise Aids (Scientific)
Burns and Scalds (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Convalescence (Scientific)
Debility (Scientific)
Fatigue (Scientific)
Liver Detoxification (Scientific)
Muscle Tone (lack of) (Scientific)
Surgery (healing from) (Scientific)
Wasting (Scientific)
Wounds and Sores (Scientific)
Ornithine ketoglutarate is used to support these body systems
Immune System (Scientific)
Liver (Scientific)
Muscles (Scientific)