Picamilon
Other names for Picamilon
4(pyridine-3carbonylamino) butanoic acid
4-(pyridine-3-carbonylamino) butanoic acid
4-(pyridine-3-carbonylamino)butanoic acid
gabatropic ffa-static substrates
nicotinoyl-gaba
n-nicotinoyl-r-aminobutyric acid
picamillion
picamilon
picamilon hcl
picamilon sodium salt
pikatro-pin
pikatropin
pikatropin picamilon
Synopsis of Picamilon
History
Picamilon, also known as N-nicotinoyl-GABA, is a unique compound synthesized by combining niacin (vitamin B3) and gamma-aminobutyric acid (GABA), both of which are naturally occurring nutrients in the body. Developed in the Soviet Union during the 1960s, picamilon was initially explored for its potential in treating a range of neurological and psychological conditions. Its historical use in Russian medicine highlights its application as an anxiolytic, neuroprotectant, and vasodilator, making it a favored remedy for anxiety, depression, and certain cognitive impairments. Importantly, picamilon's structure allows it to cross the blood-brain barrier more effectively than GABA alone, thus providing enhanced calming and mood-stabilizing effects.
Medical practitioners in Eastern Europe have traditionally prescribed picamilon for conditions such as migraines, asthenia (abnormal physical weakness), and various mood disorders. It has also been utilized in the management of alcohol withdrawal symptoms and as an aid to improve cerebral blood flow. With its dual action—combining the calming influence of GABA with the vascular support of niacin—picamilon has been praised for supporting mental clarity, reducing stress, and promoting overall neurological health.
In herbal combinations, picamilon has been blended with adaptogens such as rhodiola rosea, ashwagandha, and bacopa monnieri to further enhance its cognitive and stress-relieving properties. These combinations are sought after for their synergistic effects: while picamilon delivers focused anxiolytic and neuroprotective benefits, the herbal adaptogens bolster resilience against stress and fatigue. Overall, picamilon’s unique pharmacological profile and its positive influence on mental wellness have contributed significantly to modern nutritional and herbal formulations aimed at supporting brain health and emotional balance.
Traditional and scientific validation
Picamilon, also known as N-nicotinoyl-GABA, is a compound synthesized by combining niacin (vitamin B3) and gamma-aminobutyric acid (GABA). Developed in the Soviet Union in the 1960s, Picamilon was originally investigated for its potential to enhance cerebral blood flow and provide anxiolytic (anxiety-reducing) effects. The unique structure of Picamilon allows it to cross the blood-brain barrier more effectively than GABA alone, delivering both niacin and GABA directly to the brain, where they may support neurological function.
Several Russian clinical studies have reported that Picamilon may improve cognitive function, reduce anxiety, and alleviate symptoms associated with cerebrovascular disorders. For example, research has suggested benefits in patients with depression, migraine, and certain types of cognitive impairment. Some evidence points to its positive effects on mental performance, attention, and overall mood. Additionally, Picamilon has been explored for its potential to support recovery after stroke and to help manage symptoms of chronic fatigue syndrome.
Despite these promising reports, most scientific validation comes from studies conducted in Russia, with limited large-scale, placebo-controlled trials available in the broader scientific literature. Regulatory agencies in several countries have called for more comprehensive research to confirm its safety and efficacy. Nevertheless, Picamilon remains a noteworthy example of a compound designed to synergize two beneficial nutrients, and it continues to be used in various nutritional products for its purported cognitive and neuroprotective properties. Further research is needed to conclusively establish its benefits and optimal uses, but its unique mechanism and historical applications make it a compound of ongoing interest in the field of nootropics and neuroprotection.
Picamilon is used for these health conditions
Anxiety (Scientific)
Anxiety Disorders (Scientific)
Circulation (to the brain) (Scientific)
Fatigue (Scientific)
Memory and Brain Function (Scientific)
Neurosis (Scientific)
Stress (Scientific)
Tension (Scientific)
Thinking (cloudy) (Scientific)
Worry (Scientific)
Picamilon is used to support these body systems
Brain (Scientific)
Nerves (Scientific)
Specific Neurotransmitters (Scientific)