Rauwolscine
Other names
17a-hydroxy-20a-yohimban-16b-carboxylic acid methyl ester
17a-hydroxy-20a-yohimban-16b-carboxylic acid methyl ester hydrochloride
17a-hydroxy-yohimban-16a-carboxylic-acid methyl ester
(3)rauwolscine
alfabin
alfabin rauwolscine
alpha yohimbe
alpha yohimbine
alpha-yohimbine
alpha-yohimbine11
alpha yohimbine hcl
alpha yohimbine hydrochloride
alpha yohimbine p.e.
corynanthidine
corynanthine yohimbine
rauwlouscine
rauwolfia coryanthe
rauwolscine
rauwolscine extract
rauwolscine hcl
rawolscine
supplying rauwolscine
Synopsis
History
Rauwolscine, also known as alpha-yohimbine, is a naturally occurring alkaloid primarily derived from the roots of plants in the Rauwolfia genus, such as Rauwolfia serpentina. Historically, these plants have played a significant role in traditional medicine, especially in South Asia. For centuries, practitioners of Ayurveda and other indigenous healing systems have utilized Rauwolfia preparations to address a variety of ailments. Most notably, the roots were used as a remedy for hypertension, anxiety, and certain mental health disorders, highlighting their calming and balancing effects on the nervous system.
Beyond its use as a stand-alone botanical, rauwolscine has also been included in multiple herbal combinations. These blends often aimed to enhance cardiovascular health, support mental clarity, and promote relaxation. In traditional remedies, rauwolscine-rich extracts were sometimes combined with herbs like ashwagandha, valerian, and passionflower to synergistically modulate stress response and blood pressure. Such combinations were believed to optimize the unique properties of each herb, creating a holistic approach to wellness.
Modern research continues to uncover the potential benefits of rauwolscine, particularly in supporting metabolic health, cognitive function, and weight management. Its positive contributions can be attributed to its unique interaction with adrenergic receptors, which may aid in fat metabolism and energy regulation. Overall, rauwolscine’s rich history in medicinal use and its ongoing application in herbal formulations underscore its valuable role in natural health practices.
Traditional and scientific validation
Rauwolscine, also known as alpha-yohimbine, is a naturally occurring alkaloid found in various plants, particularly those of the Rauwolfia genus. Historically, extracts from Rauwolfia plants have been used in traditional medicine systems for their purported stimulant and aphrodisiac properties. Rauwolscine is chemically similar to yohimbine, another well-known alkaloid, and has attracted scientific interest for its potential physiological benefits.
Scientific investigations suggest that rauwolscine acts as an alpha-2 adrenergic receptor antagonist. This mechanism may promote the release of norepinephrine, potentially supporting increased energy expenditure, improved fat metabolism, and enhanced exercise performance. Some preclinical studies and limited human trials indicate that rauwolscine may aid in weight management by promoting lipolysis, though robust clinical evidence in large populations is currently lacking.
In addition to its potential metabolic effects, rauwolscine has been explored for its possible mood-enhancing and cognitive benefits, owing to its influence on neurotransmitter systems. While these findings are promising, the majority of research has been conducted in vitro or in animal models, and human studies remain limited in scope and scale.
Overall, rauwolscine represents a compelling ingredient in nutritional products, thanks to its historical use and emerging scientific insights. However, further clinical research is needed to fully substantiate its efficacy and safety in humans. As such, rauwolscine continues to be an area of active investigation, with the potential to contribute positively to the fields of nutrition and health support.
Uses: Health Conditions
Fat Metabolism (poor) (Scientific)
Weight Loss (Scientific)
Body Systems
Adrenal Medulla (Traditional)
Brain (Traditional)
Circulatory System (Traditional)
Dopamine (Traditional)
Epinephrine (Traditional)
Nerves (Traditional)
Sympathetic Nervous System (Traditional)