Secoisolariciresinol diglycoside
Synopsis of Secoisolariciresinol diglycoside
History
Secoisolariciresinol diglycoside (SDG) is a naturally occurring lignan predominantly found in flaxseed, and it has a longstanding history of traditional use in various medicinal remedies. Historically, flaxseed preparations—rich in SDG—have been utilized across cultures for their broad health benefits. In ancient Egypt, Greece, and Rome, flaxseed was renowned for its role in promoting digestive health, soothing inflammation, and supporting overall vitality. The therapeutic effects of flaxseed were often attributed to its unique phytochemical composition, with SDG being a crucial contributor.
In Ayurvedic and traditional European herbal medicine, ground flaxseed and flaxseed oil were commonly combined with other botanicals such as fenugreek, licorice root, and slippery elm to address gastrointestinal complaints, hormonal imbalances, and cardiovascular issues. These herbal blends leveraged the synergistic actions of SDG and other plant compounds to amplify health-promoting effects, particularly in supporting heart health and balancing female hormones.
Modern scientific research has validated many traditional uses of SDG. It acts as a powerful antioxidant, combats oxidative stress, and exhibits phytoestrogenic activity, which has been associated with reduced menopausal symptoms and potential protective effects against hormone-related cancers. Its cholesterol-lowering and anti-inflammatory properties further highlight its value in preventive nutrition and integrative medicine.
In summary, SDG’s historical and contemporary uses in medicinal remedies and herbal combinations underscore its versatile contributions to human health. Its integration into nutritional products continues to offer a natural, holistic approach to wellness, reflecting centuries of positive herbal wisdom.
Traditional and scientific validation
Secoisolariciresinol diglycoside (SDG) is a prominent lignan found primarily in flaxseed and has garnered scientific attention for its potential health benefits. Historically, flaxseed has been used in traditional medicine for centuries, particularly for digestive and cardiovascular support. The identification of SDG as a major bioactive compound has prompted numerous studies to explore its mechanisms and effects.
Modern research indicates that SDG possesses strong antioxidant properties, contributing to the neutralization of free radicals and reduction of oxidative stress. Several animal and in vitro studies have highlighted its potential role in supporting cardiovascular health by modulating blood lipid profiles and blood pressure. Additionally, SDG is converted by gut microbiota into enterolignans, which may exhibit estrogen-like activity, suggesting a possible benefit for hormonal balance and menopausal symptoms.
Preliminary clinical studies in humans suggest that SDG supplementation can modestly lower cholesterol levels and improve markers of metabolic health. Some trials have also explored its anti-inflammatory and cancer-preventive properties, particularly in hormone-related cancers, though results remain inconclusive. No major adverse effects have been reported in these studies, supporting its safety for use as a nutritional ingredient.
While the current body of evidence is promising, more rigorous and large-scale clinical trials are needed to fully validate the effectiveness and long-term safety of SDG. Nonetheless, its inclusion in nutritional products is supported by a growing understanding of its beneficial bioactivities and its historical use, making it a valuable ingredient for further research and health promotion.
Secoisolariciresinol diglycoside is used for these health conditions
Cancer (prevention) (Scientific)
Cardiovascular Disease (Scientific)
Cholesterol (high) (Scientific)
Diabetes (Scientific)
Inflammation (Scientific)
Secoisolariciresinol diglycoside is used to support these body systems
Circulatory System (Scientific)
Estrogen (Scientific)
Female Reproductive System (Scientific)
Heart (Scientific)