Serrazimes (proprietary) (serrazimes )
Synopsis of serrazimes (proprietary)
Serrazimes is a proprietary enzyme blend designed to mimic the activity of serratiopeptidase (serrapeptase), a well-known systemic proteolytic enzyme. Developed as a vegetarian and non-animal alternative, Serrazimes typically includes a combination of protease enzymes derived from fungal sources—most notably Aspergillus melleus and Aspergillus oryzae. These enzymes exhibit fibrinolytic and proteolytic activity, meaning they help break down proteins, fibrin (a clotting factor), and metabolic debris that may contribute to inflammation and tissue congestion.
Serrazimes is promoted for its anti-inflammatory and tissue-repair-supportive properties, much like serrapeptase. It is often used in systemic enzyme therapy to support joint health, reduce post-exercise muscle soreness, assist with sinus and respiratory congestion, and accelerate recovery from surgery or trauma. Because it is derived from fungal fermentation, Serrazimes is considered suitable for vegetarians and those who avoid animal-derived ingredients—making it an appealing option for a wider demographic compared to traditional serratiopeptidase, which originates from silkworm bacteria.
While clinical research specifically on Serrazimes is limited compared to serratiopeptidase, in vitro studies suggest that it possesses comparable proteolytic strength. It is often used in nutraceutical formulations marketed for inflammation, cardiovascular support, scar tissue breakdown, and immune modulation. Like all systemic enzymes, Serrazimes must be taken on an empty stomach to be absorbed into the bloodstream and act throughout the body rather than just in the digestive tract.
Historical Use:
Though Serrazimes itself is a modern, laboratory-engineered formula with no direct historical precedent, it draws on centuries-old knowledge of proteolytic enzyme therapy. Traditional cultures have long used naturally occurring enzyme sources—such as papaya (papain), pineapple (bromelain), and fermented foods—to reduce inflammation, soften tissues, aid digestion, and accelerate healing. In particular, Asian cultures that consumed natto (fermented soybeans) were unknowingly supplementing with nattokinase, another enzyme with fibrinolytic properties.
The emergence of serratiopeptidase in 20th-century Japan set the stage for the development of plant-based enzyme alternatives like Serrazimes. As serrapeptase gained popularity in clinical settings for managing post-operative inflammation and ENT (ear, nose, throat) conditions, demand grew for vegan-compatible versions. This led to the development of fungal-derived proteolytic complexes capable of delivering similar systemic effects.