Squalene
Synopsis of Squalene
History
Squalene, a naturally occurring triterpene, has a rich history of use in traditional medicine, particularly in Mediterranean and Asian cultures. Originally discovered in shark liver oil, squalene has also been sourced from olives, amaranth seeds, and certain vegetable oils. Historically, it has been prized for its purported ability to enhance vitality and promote longevity. In ancient remedies, shark liver oil containing squalene was utilized to support immune health, accelerate wound healing, and boost overall resilience against illnesses. Fishermen in Japan and Scandinavia, for instance, consumed shark liver oil as a folk remedy to increase their stamina and recover from fatigue.
Its antioxidant properties have made squalene a valuable component in herbal medicine combinations. Herbalists often blend squalene-rich oils with botanicals like calendula, chamomile, and rosemary to create salves and topical treatments for skin rejuvenation and inflammation relief. Its ability to support cellular health and enhance nutrient absorption has also led to its inclusion in oral herbal supplements, where it is combined with immune-supportive herbs like echinacea and astragalus.
Modern research corroborates many of these traditional uses, highlighting squalene’s contributions to skin health, immune modulation, and antioxidant defense. Its compatibility with both herbal and nutritional formulations underscores its versatility and enduring value. Squalene continues to be recognized as a safe, effective, and natural ingredient with a proud legacy in the world of holistic wellness.
Traditional and scientific validation
Squalene is a naturally occurring triterpene compound found abundantly in shark liver oil, as well as in certain plant sources such as olive oil, amaranth seed, and rice bran. Historically, squalene was valued in traditional medicine, particularly in East Asia, for its reputed ability to enhance vitality and support immune function. In the 20th century, squalene garnered scientific attention due to its role as a precursor in cholesterol and steroid hormone biosynthesis in the human body.
Contemporary research has explored squalene's potential health benefits, especially its antioxidant and skin-protective properties. Studies suggest squalene may help neutralize free radicals, contributing to cellular protection and supporting skin moisture and elasticity. Some clinical investigations have examined its use as a dietary supplement to improve lipid profiles and bolster immune responses, with certain findings indicating a positive effect on cholesterol levels and immune cell activity. Additionally, squalene is recognized as a valuable adjunct in vaccine formulations, where it serves as an adjuvant to enhance immune response.
Despite these promising indications, the evidence base for many claimed health benefits remains limited, and large-scale, well-controlled human trials are still needed to conclusively establish squalene’s efficacy in nutrition and disease prevention. Nonetheless, its long history of use and emerging scientific data support its continued exploration as a beneficial ingredient in nutritional products. Squalene’s safety profile is generally regarded as favorable, further justifying its role in both traditional and modern health applications.
Squalene is used for these health conditions
Aging (prevention) (Scientific)
Dermatitis (Scientific)
Eczema (Scientific)
Free Radical Damage (Scientific)
Hair Care (general) (Scientific)
Inflammation (Scientific)
Squalene is used to support these body systems
Immune System (Scientific)
Skin (Scientific)