Vitamin B3 (Nicotinamide riboside)
Synopsis of Vitamin B3 (Nicotinamide riboside)
History
Vitamin B3, particularly in the form of nicotinamide riboside (NR), has a rich legacy in the realm of nutritional and medicinal applications. Historically, the broader category of vitamin B3—encompassing niacin, nicotinamide, and later, nicotinamide riboside—was recognized for its remarkable ability to prevent and treat pellagra, a disease marked by dermatitis, diarrhea, and dementia. Early 20th-century physicians utilized vitamin B3-rich foods and supplements as remedies for this once-prevalent condition, dramatically improving public health outcomes.
Nicotinamide riboside, a newer and more bioavailable form of vitamin B3, has gained attention for its ability to boost cellular NAD+ levels, a molecule essential for energy metabolism and DNA repair. Traditional remedies often used foods high in vitamin B3, such as brewer’s yeast and certain herbs, to restore vitality, improve cognitive function, and support skin health. Today, NR is celebrated for its potential to promote healthy aging, enhance mitochondrial function, and provide neuroprotective benefits.
In herbal combinations, vitamin B3 is frequently paired with adaptogenic herbs like ashwagandha, ginseng, and rhodiola, amplifying the body’s resilience to stress and fatigue. It also partners well with antioxidant-rich botanicals such as green tea and turmeric, supporting overall wellness and cellular health. These synergies underscore vitamin B3’s positive contributions, offering a foundation for modern supplements aimed at holistic vitality and longevity.
Traditional and scientific validation
Nicotinamide riboside (NR), a form of vitamin B3, has attracted significant interest as a nutritional supplement due to its role as a precursor to nicotinamide adenine dinucleotide (NAD+), a vital molecule involved in cellular metabolism and energy production. Historically, vitamin B3 has been recognized for its essential function in preventing pellagra, a disease characterized by dermatitis, diarrhea, and dementia. In recent years, NR has emerged as a promising compound based on its ability to effectively boost NAD+ levels in the body.
Scientific studies have demonstrated that supplementation with NR can increase NAD+ concentrations in blood and tissue, which may support mitochondrial function and cellular repair processes. Preliminary clinical trials in humans suggest that NR supplementation is safe and well-tolerated, with potential benefits for cardiovascular health, neuroprotection, and metabolic function. For instance, research has indicated that NR may improve markers of cardiovascular health, enhance muscle performance in older adults, and support overall metabolic health.
While these findings are promising, it is important to note that most studies to date have been small and of short duration. The long-term effects and specific health benefits of NR supplementation require further investigation through larger, well-controlled clinical trials. Nonetheless, the scientific community remains optimistic about NR’s potential, and its inclusion in nutritional products is supported by a growing body of evidence indicating its role in supporting cellular energy and healthy aging. As research progresses, NR may become an even more valuable tool for promoting wellness and longevity.
Vitamin B3 (Nicotinamide riboside) is used for these health conditions
Aging (prevention) (Scientific)
Alzheimer's Disease (Scientific)
Cancer (natural therapy for) (Scientific)
Cardiovascular Disease (Scientific)
Cholesterol (high) (Scientific)
Chronic Obstructive Pulmonary Disorder (Scientific)
Colitis (Scientific)
Depression (Scientific)
Diabetes (Scientific)
Fatigue (Scientific)
Fatty Liver Disease (Scientific)
Inflammation (Scientific)
Memory and Brain Function (Scientific)
Metabolic Syndrome (Scientific)
Migraine (Scientific)
Nerve Damage (Scientific)
Triglycerides (high) (Scientific)
Vitamin B3 (Nicotinamide riboside) is used to support these body systems
Blood (Scientific)
Brain (Scientific)
Circulatory System (Scientific)
Heart (Scientific)
Immune System (Scientific)
Liver (Scientific)
Mitochondria (Scientific)
Nerves (Scientific)
Skin (Scientific)