Vitamin B9
Other names for Vitamin B9
5-methyltetrahydrofolate
(6s)-5-methyltetrahydrofolic acid calcium salt
(6s)-n5-methyltetrahydrofolic acid calcium salt
biofolate
calcium 5-formyltetrahydrofolate
calcium 5-methyltetrahydrofolate
calcium (6s)-5-methyltetrahydrofolate
calcium l-methylfolate
extrafolate-s
folate
l-5-methylfolate
l-5 methyltetrahydrofolate calcium
l-5-methyltetrahydrofolate calcium
levomefolate calcium
levomefolic acid
l-methylfolate
l-methylfolate calcium
l-methylfolate calcium salt
magnafolate-c
methylated folate
methyltetrahydrofolate
vitamin b9
Synopsis of Vitamin B9
History
Vitamin B9, also known as folate or folic acid (in its synthetic form), has a rich history in medicinal and nutritional practices. Traditionally, before its isolation as a distinct vitamin in the 20th century, the health benefits of folate-rich foods—such as leafy greens, legumes, and liver—were celebrated in many cultures. Folk medicine often recommended these foods to treat fatigue, anemia, and to promote overall vitality, especially in women of childbearing age. These early remedies hinted at the essential role that Vitamin B9 plays in red blood cell formation and cellular growth.
With the discovery of folate’s structure in the 1940s, its use in medicine became more targeted. It quickly became a cornerstone in the prevention and treatment of megaloblastic anemia, a condition marked by the production of abnormally large red blood cells, which was especially common among pregnant women and individuals with poor diets. The fortification of grain products with folic acid in many countries has since led to a significant reduction in neural tube defects in newborns, underscoring its vital role in prenatal health.
In herbal medicine, Vitamin B9 is often found naturally in combination with other B vitamins and nutrients within plant-based remedies. These herbal combinations, such as blends including nettle, alfalfa, and dandelion, are traditionally used to support energy, blood health, and women’s reproductive wellness. The synergistic effect of these herbs not only provides a natural source of folate but also enhances the body’s overall nutrient absorption. Overall, Vitamin B9 remains a celebrated nutrient, both in traditional and modern contexts, for its profound contributions to health and healing.
Traditional and scientific validation
Vitamin B9, also known as folate or folic acid (in its synthetic form), has long been recognized as a vital nutrient for human health. Its historical significance emerged in the early 20th century when researchers noted that certain types of anemia, particularly in pregnant women, could be alleviated by consuming foods rich in leafy greens. The isolation of folate in the 1940s paved the way for its incorporation into nutritional products and prenatal supplements.
Scientifically, vitamin B9 is essential for DNA synthesis, cell division, and growth, making it especially important during periods of rapid development, such as pregnancy and infancy. Numerous clinical studies have validated its use in preventing neural tube defects (NTDs) in newborns. For example, a landmark randomized controlled trial published in The Lancet (1991) demonstrated that periconceptional supplementation with folic acid significantly reduced the risk of NTDs. This evidence led to the widespread fortification of foods with folic acid in many countries and is considered a public health success.
Additionally, research suggests that adequate folate intake may play a role in cardiovascular health by lowering homocysteine levels, although the direct impact on heart disease prevention remains under investigation. While ongoing studies continue to explore its broader benefits and limitations, the scientific consensus supports vitamin B9’s critical role in prenatal nutrition and its contribution to overall well-being. Continued research will help clarify its full potential in other health domains.
Vitamin B9 is used for these health conditions
Alzheimer's Disease (Scientific)
Anemia (Scientific)
Autism (Scientific)
Cancer (prevention) (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Concentration (poor) (Scientific)
Dementia (Scientific)
Depression (Scientific)
Memory and Brain Function (Scientific)
Miscarriage (prevention) (Scientific)
Pregnancy (herbs and supplements for) (Scientific)
Vitamin B9 is used to support these body systems
Arteries (Scientific)
Blood (Scientific)
Brain (Scientific)
Female Reproductive System (Scientific)
Gastrointestinal Tract (Scientific)
Heart (Scientific)
Immune System (Scientific)
Liver (Scientific)
Male Reproductive System (Scientific)
Nerves (Scientific)
Ovaries (Scientific)
Reproductive System (Scientific)
Skin (Scientific)
Small Intestines (Scientific)
Uterus (Scientific)