Other names for Vitamin B9 (methyltetrahydrofolate)

5-methyltetrahydrofolate
(6s)-5-methyltetrahydrofolate
6(s)-5-methyltetrahydrofolic acid
(6s)-5-methyltetrahydrofolic acid
[6s]-5-methyltetrahydrofolic acid
(6s)-5-methyltetrahydrofolic acid, calcium salt
(6s)-5-mthf
calcium 5-methyltetrahydrofolate
calcium-l-5-methyltetrahydrofolate
folate
l-5-methyltetrahydrofolate
l-5 methyltetrahydrofolate calcium salt
l-methylfolate
metafolin l-5-methyltetrahydrofolate

Synopsis of Vitamin B9 (methyltetrahydrofolate)

History

Vitamin B9, commonly known as folate or its active form methyltetrahydrofolate, has a rich history in medicinal and nutritional practices. Traditionally, diets rich in leafy green vegetables, legumes, and certain herbs—natural sources of folate—were long valued by ancient cultures for their health-promoting properties. Though the vitamin itself was isolated in the 20th century, ancient remedies often included folate-rich ingredients to treat conditions like anemia, fatigue, and complications related to pregnancy. Midwives and herbalists would recommend infusions of nettle, spinach, or parsley, not only for their general vitality-boosting effects but also, as we now understand, for their folate content supporting red blood cell formation and fetal development.

With the discovery of folate’s essential role in DNA synthesis and repair, its medicinal significance grew. Methyltetrahydrofolate, the bioactive form, is especially prized today for its superior absorption and efficacy, particularly for individuals with MTHFR gene polymorphisms who cannot efficiently convert folic acid to its active form. This makes it a cornerstone in prenatal supplements, energy blends, and formulations aimed at heart and cognitive health.

In modern herbal combinations, methyltetrahydrofolate is frequently paired with B12, iron, and traditional botanicals like ashwagandha or ginkgo. These synergies enhance metabolic processes, improve mood, and support overall well-being. The enduring legacy of B9 in both ancient and contemporary remedies underscores its remarkable contributions to human health, making it an indispensable ingredient in nutritional products and holistic therapies alike.

Traditional and scientific validation

Vitamin B9, commonly referred to as folate or folic acid, is an essential water-soluble B vitamin that plays a critical role in DNA synthesis, repair, and methylation, as well as in amino acid metabolism. The active form, methyltetrahydrofolate (5-MTHF), is increasingly used in nutritional products due to its superior bioavailability compared to synthetic folic acid, especially in individuals with genetic variations such as MTHFR polymorphisms.

Historically, folate deficiency has been linked to megaloblastic anemia and neural tube defects (NTDs) in newborns. Landmark studies in the late 20th century demonstrated that prenatal folic acid supplementation significantly reduced the risk of NTDs, leading to food fortification policies worldwide. More recent research suggests that supplementation with 5-MTHF may have advantages over folic acid, as it bypasses enzymatic conversion steps and is more effective for people with impaired folate metabolism.

Clinical trials have explored the benefits of 5-MTHF in supporting cardiovascular health by reducing homocysteine levels, a risk factor for cardiovascular disease. Some studies also indicate potential roles in mood regulation and cognitive function, although evidence remains preliminary. The scientific consensus supports the importance of adequate folate intake, and 5-MTHF is recognized as a potent, bioactive source. However, more research is needed to fully elucidate its unique benefits over folic acid in diverse populations. Overall, methyltetrahydrofolate is a well-validated nutrient that contributes positively to health, particularly in individuals with increased folate requirements or compromised folate metabolism.

Vitamin B9 (methyltetrahydrofolate) is used for these health conditions

Alzheimer's Disease (Scientific)
Anemia (Scientific)
Autism (Scientific)
Birth Defects (prevention) (Scientific)
Cancer (natural therapy for) (Scientific)
Cancer (prevention) (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Cardiovascular Disease (Scientific)
Dementia (Scientific)
Depression (Scientific)
Diabetes (Scientific)
Infertility (Scientific)
Memory and Brain Function (Scientific)
Miscarriage (prevention) (Scientific)
Pregnancy (herbs and supplements for) (Scientific)

Vitamin B9 (methyltetrahydrofolate) is used to support these body systems

Blood (Scientific)
Brain (Scientific)
Circulatory System (Scientific)
Female Reproductive System (Scientific)
Gastrointestinal Tract (Scientific)
Immune System (Scientific)
Intestinal System (Scientific)
Male Reproductive System (Scientific)
Nerves (Scientific)
Ovaries (Scientific)
Reproductive System (Scientific)
Small Intestines (Scientific)
Uterus (Scientific)

Products containing Vitamin B9 (methyltetrahydrofolate)

We currently have no products on Vitabase that contain this ingredient.