Pancreatin

Table of Contents

Other names

Pancreatic Enzymes
Pancrelipase
Porcine Pancreatin

Synopsis

Pancreatin is a blend of digestive enzymes naturally produced by the pancreas and typically extracted from the pancreas of pigs or cows for therapeutic use. It contains a combination of amylase (for starch breakdown), lipase (for fat digestion), and protease (for protein digestion). Pancreatin is used as a digestive aid in individuals who have insufficient enzyme production, a condition known as exocrine pancreatic insufficiency (EPI).

Common medical indications include chronic pancreatitis, cystic fibrosis, pancreatic cancer, and post-surgical pancreatic conditions (such as Whipple procedure or pancreatectomy). Supplementing with pancreatin helps improve nutrient absorption, reduce fatty stools (steatorrhea), and alleviate bloating, gas, and malnutrition associated with enzyme deficiencies.

In functional and integrative medicine, pancreatin is also used to support general digestive health, particularly in aging individuals with declining enzyme production, or those with heavy or high-fat meals. Some studies suggest pancreatin may reduce postprandial discomfort and improve symptoms of functional dyspepsia.

Pancreatin is available in various forms—enteric-coated tablets, capsules, and powders—with different enzyme potencies, typically measured in USP (United States Pharmacopeia) units. High-potency versions are often prescription-only (e.g., Creon, Pancreaze), while lower-dose forms are available over the counter.

Historical Use in Medicine
The therapeutic use of pancreatin began in earnest in the 19th century, following advances in understanding the role of pancreatic secretions in digestion. In 1857, Claude Bernard first demonstrated the function of pancreatic juice in breaking down food, leading to the eventual development of enzyme extracts for medical use.

By the early 20th century, pancreatin was commercially produced and used to treat indigestion, malabsorption, and pancreatic insufficiency. It was included in many compound digestive tonics and natural enzyme blends, often combined with bile salts or hydrochloric acid for broader gastrointestinal support.

As medical understanding evolved, pancreatin became a cornerstone treatment for cystic fibrosis, where thickened secretions obstruct pancreatic enzyme release, leading to malnutrition. Similarly, it became standard care for chronic pancreatitis, especially in alcohol-induced or hereditary cases.

In naturopathic and holistic traditions, enzyme therapy—including pancreatin—has also been explored for its systemic effects, including anti-inflammatory and immune-modulating properties, though these uses remain more controversial and less well-supported by clinical trials.

Today, pancreatin is an essential component of enzyme replacement therapy (ERT) and plays a critical role in maintaining digestive and nutritional health in patients with pancreatic disorders.

Uses: Health Conditions

None

Body Systems

Digestive System (Science)
Gastrointestinal Tract (Science)
Pancreas Head (Science)
Pancreatic Tail (Science)
Stomach (Science)