Aloe polysaccharides, primarily acemannan and related mannose-rich compounds found in Aloe vera gel, have been investigated for their wound-healing properties, including their use in treating minor abrasions. Several in vitro and in vivo studies suggest that Aloe polysaccharides can support wound healing by promoting fibroblast proliferation, enhancing collagen synthesis, and exerting anti-inflammatory and antimicrobial effects. For example, research published in Phytotherapy Research (2015) and Journal of Ethnopharmacology (2012) demonstrated that Aloe vera gel accelerates wound closure in animal models, and these effects are attributed largely to its polysaccharide content.

Clinical data in humans are more limited, but some small randomized controlled trials have reported faster healing of minor wounds and abrasions with topical Aloe gel compared to placebo. However, results are mixed, and methodological quality varies; some reviews, such as a 2012 Cochrane review, concluded that while Aloe vera may slightly speed up wound healing, the evidence is not robust due to small sample sizes and inconsistent results. Traditional use of Aloe vera for skin healing provides additional support, but the direct link to isolated polysaccharides is primarily supported by preclinical studies. Overall, Aloe polysaccharides are scientifically plausible agents for supporting abrasion healing, but the clinical evidence remains moderate and does not warrant a strong recommendation.