Evidence supporting the use of: Growth factors
For the health condition: Abrasions

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Growth factors are proteins that play a crucial role in the regulation of cell growth, proliferation, and healing. Their use in the treatment of abrasions is scientifically validated, with a moderate to high level of supporting evidence. Several preclinical and clinical studies have demonstrated that exogenously applied growth factors—such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and basic fibroblast growth factor (bFGF)—can accelerate re-epithelialization, enhance tissue regeneration, and reduce healing time in superficial wounds, including abrasions.

Growth factors work by stimulating the migration and proliferation of keratinocytes and fibroblasts, which are essential for wound closure and tissue repair. For example, recombinant human PDGF is approved by the FDA for certain types of chronic wounds, and clinical trials have shown promising results when topical growth factors are used on acute wounds like abrasions. Meta-analyses and systematic reviews suggest that topical application of these agents can improve healing outcomes, although the degree of benefit may depend on the specific type of growth factor and formulation used.

Despite the supportive evidence, practical use is sometimes limited by cost, formulation stability, and accessibility. Nonetheless, the current consensus in wound care supports the adjunctive use of growth factors for enhancing the healing of abrasions, especially in cases where conventional treatments are insufficient.

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Products containing Growth factors

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