Platelet-derived growth factor (PDGF) is scientifically validated for its role in wound healing, including the treatment of abrasions. PDGF is a naturally occurring protein in the body that regulates cell growth and division, particularly in blood vessel formation (angiogenesis) and the repair of connective tissue. Its use in wound care is primarily based on its ability to stimulate the proliferation and migration of fibroblasts and smooth muscle cells, which are crucial for tissue repair and regeneration.

Clinical evidence supports the application of recombinant human PDGF (becaplermin gel) for certain types of wounds, such as diabetic foot ulcers. While most studies and regulatory approvals focus on chronic wounds, the biological rationale for PDGF’s effectiveness applies to acute wounds like abrasions as well. Several in vitro and animal studies have demonstrated enhanced re-epithelialization and faster wound closure with PDGF treatment. The FDA has approved PDGF-containing products for wound healing, further supporting its scientific basis.

However, direct clinical trials on PDGF specifically for simple abrasions in otherwise healthy individuals are limited. Most human data are extrapolated from studies on more complex or chronic wounds. Despite this, the general mechanism of PDGF in promoting tissue repair and regeneration underpins its use in supporting the healing of abrasions.