Prolase is a topical preparation that contains proteolytic enzymes, primarily collagenase, which is used in the management of wounds, including abrasions. The scientific rationale behind its use lies in its enzymatic debridement activity: collagenase selectively breaks down denatured collagen in necrotic tissue, thereby facilitating the removal of non-viable tissue from wounds and promoting natural healing. Several studies and clinical guidelines support the use of collagenase ointment for chronic wounds, burns, and ulcers, where debridement is a critical step in care. Its application in minor abrasions is less specifically studied, but the mechanism suggests it may aid in cases where slough or necrotic material is present, or where healing is delayed due to a buildup of devitalized tissue. The evidence for its use in simple abrasions (i.e., superficial skin scrapes without significant necrosis) is limited, as these typically heal without intervention, but in more complex or slow-healing abrasions, enzyme preparations like Prolase may be beneficial.

The overall quality of evidence is moderate, with most support coming from case series, older studies, and extrapolation from research on other wound types. There is a lack of large-scale randomized controlled trials specifically focused on abrasions, which limits the evidence rating to 3 out of 5. Nonetheless, Prolase's use in wound care is well-accepted in medical practice, and its safety profile is favorable for topical application.