Evidence supporting the use of: Transforming growth factor
For the health condition: Abrasions

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Transforming Growth Factor (TGF), particularly TGF-β, is scientifically validated as an important cytokine in the process of wound healing, including the treatment of abrasions. TGF-β regulates many cellular processes essential to wound repair, such as inflammation, cell proliferation, differentiation, and extracellular matrix production. Experimental and clinical studies have shown that TGF-β is upregulated in the early stages of wound healing and plays a critical role in promoting the migration and proliferation of fibroblasts and keratinocytes, which are necessary for re-epithelialization of abrasions and other superficial wounds.

Topical application of TGF-β or its analogs has been explored in various preclinical models, where it has been shown to accelerate the closure of superficial wounds by enhancing granulation tissue formation and collagen deposition. Reviews and meta-analyses of animal studies support the beneficial effects of TGF-β in wound healing, particularly in situations where healing is impaired. However, its use is not yet standard in routine clinical practice for abrasions, partly due to concerns over potential risks such as fibrosis or scarring with excessive or uncontrolled application. Nonetheless, the molecular and experimental evidence strongly supports the role of TGF-β in facilitating abrasion healing, and the rating of 4 reflects this robust preclinical and mechanistic foundation, even if widespread clinical adoption is still developing.

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