Evidence supporting the use of: Transforming growth factor
For the health condition: Abrasions
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Transforming Growth Factor (TGF), particularly TGF-β, is scientifically validated as an important cytokine in the process of wound healing, including the treatment of abrasions. TGF-β regulates many cellular processes essential to wound repair, such as inflammation, cell proliferation, differentiation, and extracellular matrix production. Experimental and clinical studies have shown that TGF-β is upregulated in the early stages of wound healing and plays a critical role in promoting the migration and proliferation of fibroblasts and keratinocytes, which are necessary for re-epithelialization of abrasions and other superficial wounds.
Topical application of TGF-β or its analogs has been explored in various preclinical models, where it has been shown to accelerate the closure of superficial wounds by enhancing granulation tissue formation and collagen deposition. Reviews and meta-analyses of animal studies support the beneficial effects of TGF-β in wound healing, particularly in situations where healing is impaired. However, its use is not yet standard in routine clinical practice for abrasions, partly due to concerns over potential risks such as fibrosis or scarring with excessive or uncontrolled application. Nonetheless, the molecular and experimental evidence strongly supports the role of TGF-β in facilitating abrasion healing, and the rating of 4 reflects this robust preclinical and mechanistic foundation, even if widespread clinical adoption is still developing.
Other ingredients used for Abrasions
aloe verabeeswax
bisabolol
chamomile
turmeric
glycerin
goldenseal
gotu kola
hyaluronic acid
lavender
licorice root
microbial enzymes (proprietary)
mucin
plantain
protease
purified silver
slippery elm bark
vitamin C
zinc
chickweed
xanthium (cockleburs)
shen-chu
nut grass
clerodendrum indicum
paederia foetida
boxthorne
yarrow
moss
myrrh
siler root
oriental arborvitae
assam indigo
paw paw
white oak
melaleuca alternifolia
geranium
arnica
sea salt
Ash
Avens
Asiaticoside
acacia
Agave
Agrimony
Antirrhinum majus
Achyranthes
Anamu
Abrus
Alchornea
Alchemilla
Ajuga
Aquilegia formosa
Allantoin
Alkanet
Alsonia scholaris
Ampelopsis
Abuta
Alkanna
Bee Propolis
Bai Ji
Blackthorn
Balsam
Blackbrush
Butea monosperma
Barleria
Brazillian peppertree
Bee hive
Bloodroot
Benzoin
Bindweed
Banyan
Bletilla
Bee products
Bombax
Boerhavia diffusa
Calochortus
Comfrey
Centella triterpenes
Calendula
Calotropis gigantea
Colloidal Silver
Capillary Artemisia
Cinquefoil
Cattail
Cocoa Butter
Cymbidium goeringii
Cornflower
Cowherb
Centella asiatica
Celandine
Centipeda
Carrapichinho
Cedrus libani
Castile Soap
Cynodon dactylon
Cocklebur
Cynanchum
Casearia sylvestris
Didymocarpus
Dragon's Blood
Davilla rugosa
Epidermal Growth Factor
Erigeron
Elephant Vine
Erodium cicutarium
English Elm
Elephant's Head
Euphorbia
Flueggea suffruticosa
Ficin
Fibrinase
fibroblast growth factor
Fir
Little ironweed
Oak
Polyvinyl alcohol
Other health conditions supported by Transforming growth factor
AbrasionsArthritis
Autoimmune Disorders
Bruises (healing)
Burns and Scalds
Cancer Treatment (reducing side effects)
Chemotherapy (reducing side effects)
Cuts
Inflammation
Injuries
Ligaments (torn or injured)
Nerve Damage
Osteoporosis
Scars / Scar Tissue
Surgery (healing from)
Wounds and Sores