Evidence supporting the use of: Transforming growth factor beta
For the health condition: Abrasions

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Transforming growth factor beta (TGF-β) is justified for use in supporting or treating abrasions based on scientific evidence. TGF-β is a multifunctional cytokine that plays a pivotal role in wound healing, including the repair of skin abrasions. Scientific studies have demonstrated that TGF-β modulates inflammation, stimulates fibroblast proliferation, enhances collagen synthesis, and promotes re-epithelialization—key processes in wound repair. Experimental models, including animal studies and in vitro assays, have shown that application of TGF-β accelerates closure of abrasions and improves the quality of healing tissue. Furthermore, TGF-β is involved in the recruitment of immune cells and regulation of extracellular matrix production, both vital for effective tissue regeneration. However, while preclinical data are robust, clinical trials in humans are relatively limited, often due to concerns about excessive scarring or fibrosis with unregulated TGF-β activity. Some wound care products and experimental therapies incorporate TGF-β or its analogs to leverage these healing properties. In summary, the use of TGF-β for treating abrasions is supported by substantial mechanistic and experimental evidence, though more clinical research is warranted to optimize its therapeutic application and mitigate potential adverse effects such as hypertrophic scarring.

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