Evidence supporting the use of: Hyaluronidase
For the health condition: Abscesses

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hyaluronidase is an enzyme that breaks down hyaluronic acid in connective tissue, increasing tissue permeability. Its use in the management of abscesses is supported by scientific rationale and some clinical evidence, although it is not a first-line treatment. The primary scientific basis for its use is to facilitate the dispersion and absorption of other substances, such as antibiotics or local anesthetics, into tissue, potentially aiding in the resolution of localized infections or abscesses. In some cases, hyaluronidase is injected around an abscess to enhance the spread of antibiotics or to help with the infiltration of local anesthetics prior to incision and drainage procedures. Clinical studies and case reports have described improved outcomes in terms of reduced tissue induration and more effective anesthesia, but large-scale, high-quality randomized controlled trials specifically focusing on abscess treatment are lacking. Most guidelines still recommend incision and drainage as the mainstay of abscess management, with hyaluronidase serving as an adjunct in select cases, particularly in deep-seated or difficult-to-access abscesses. Overall, the evidence base for hyaluronidase in abscess treatment is moderate, with its use supported by mechanistic reasoning and limited clinical data rather than robust, high-level studies.

More about Hyaluronidase
More about Abscesses

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Products containing Hyaluronidase

We currently have no products on Vitabase that contain this ingredient.