Evidence supporting the use of: Trypsin
For the health condition: Abscesses

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trypsin, a proteolytic enzyme obtained from the pancreas, has been studied and used as an adjunctive treatment for abscesses and similar inflammatory conditions, particularly in some Asian and European countries. The rationale for its use is based on trypsin's ability to break down proteins, which may help liquefy pus and necrotic tissue within an abscess, thereby facilitating drainage and healing. Some animal studies and small clinical trials have indicated that proteolytic enzymes like trypsin can reduce inflammation, promote the resorption of exudates, and accelerate tissue repair.

However, the scientific evidence supporting its use is limited and of low quality. Most of the available data come from older studies or reports with small sample sizes, lack of rigorous study design, or combined preparations (such as trypsin with chymotrypsin or other enzymes), making it difficult to isolate the effect of trypsin alone.

Standard treatment for abscesses remains incision and drainage, often combined with antibiotics. Enzyme therapy, including trypsin, is generally considered as an adjunct rather than a replacement for these established therapies. Systematic reviews and clinical guidelines do not recommend proteolytic enzymes as a primary treatment for abscesses, citing insufficient robust evidence.

In summary, while there is some scientific basis and limited clinical support for the use of trypsin in managing abscesses, the strength of evidence is weak, and it should not be considered a mainline therapy.

More about trypsin
More about Abscesses

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