Evidence supporting the use of: Alpha glyceryl
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha glyceryl (more accurately, alpha-GPC or L-alpha glycerylphosphorylcholine) is a choline compound used to support the acetylcholine system in the body. Acetylcholine is a key neurotransmitter involved in memory, learning, and muscle contraction. Alpha-GPC serves as a precursor to acetylcholine and is able to cross the blood-brain barrier efficiently, increasing choline availability in the brain.

There is scientific evidence supporting its role in boosting acetylcholine synthesis. Several randomized, placebo-controlled studies have shown that alpha-GPC supplementation can improve cognitive function in individuals with cognitive decline, such as those with Alzheimer’s disease and vascular dementia. For example, a 2003 review (Drugs & Aging) found that alpha-GPC improved cognitive symptoms more than placebo in elderly patients with dementia. Animal studies also indicate enhanced acetylcholine release and improved learning and memory performance with alpha-GPC supplementation.

In healthy individuals, evidence is more limited but still suggests potential cognitive benefits, particularly in the context of attention and memory. There is also some research in athletes indicating possible enhancement of physical performance, likely via increased acetylcholine-mediated muscle contraction.

Overall, alpha-GPC is scientifically validated as a choline donor supporting the acetylcholine system, though its benefits are best established in populations with cognitive impairment. The strength of evidence in healthy individuals and for non-cognitive uses is moderate but growing.

More about Alpha glyceryl
More about Acetylcholine

Other body systems supported by Alpha glyceryl

Acetylcholine
Brain
Nerves
Specific Neurotransmitters

Products containing Alpha glyceryl

We currently have no products on Vitabase that contain this ingredient.