Evidence supporting the use of: Alpha-GPC
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a choline-containing compound that has been studied for its effects on acetylcholine levels in the brain. Acetylcholine is a key neurotransmitter involved in memory, learning, and muscle contraction. Alpha-GPC serves as a precursor to acetylcholine and can cross the blood-brain barrier efficiently. Scientific studies, primarily in the context of cognitive decline and neurological disorders, have shown that Alpha-GPC supplementation increases acetylcholine synthesis and release. Clinical trials, particularly in Europe, have demonstrated modest improvements in cognitive function in patients with Alzheimer’s disease and vascular dementia when compared to placebo or other choline sources. For example, a 2003 review (Parnetti et al., Clinical Therapeutics) summarized evidence suggesting cognitive benefits, though many studies were small or had methodological limitations. There are also some studies showing enhancement of physical performance and power output, likely due to improved neuromuscular transmission via elevated acetylcholine levels. However, robust evidence in healthy adults is limited, and the majority of high-quality research focuses on populations with cognitive impairment. Overall, the use of Alpha-GPC to support the acetylcholine system is scientifically plausible and partially validated, but more large-scale, high-quality studies are needed to establish its efficacy in broader populations.

More about Alpha-GPC
More about Acetylcholine

Other body systems supported by Alpha-GPC

Acetylcholine
Brain
Nerves
Specific Neurotransmitters

Products containing Alpha-GPC

We currently have no products on Vitabase that contain this ingredient.