Evidence supporting the use of: Bacosides (mixed)
For the body system: Acetylcholine

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacosides, the active compounds found in Bacopa monnieri (commonly known as Brahmi), have been the subject of several scientific studies investigating their effects on the cholinergic system, particularly acetylcholine, a key neurotransmitter involved in memory and cognition. Preclinical research indicates that bacosides may enhance cholinergic function by increasing acetylcholine synthesis, inhibiting acetylcholinesterase (the enzyme that breaks down acetylcholine), and upregulating choline acetyltransferase (the enzyme involved in acetylcholine production). Animal studies have shown improvements in memory and learning, which are often attributed to these mechanisms.

Human clinical trials, while limited and generally small in scale, have reported modest cognitive benefits in healthy adults, elderly individuals, and those with cognitive impairment. Systematic reviews and meta-analyses suggest that Bacopa monnieri supplementation may improve some aspects of memory and attention, potentially due to its influence on acetylcholine pathways. However, direct evidence linking bacosides to changes in acetylcholine levels in humans is still preliminary, and more robust, large-scale studies are needed.

In summary, while the historical use of Bacopa is rooted in traditional medicine, there is emerging scientific validation for its impact on the acetylcholine system, warranting a moderate evidence rating.

More about Bacosides (mixed)
More about Acetylcholine

Other body systems supported by Bacosides (mixed)

Acetylcholine
Brain
Hypothalamus
Nerves
Parasympathetic Nervous System
Serotonin

Products containing Bacosides (mixed)

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