Brahmi (Bacopa monnieri) is an herb traditionally used in Ayurvedic medicine for cognitive enhancement and neurological health. Modern scientific research has investigated its effects on cognitive function, with particular attention to its impact on acetylcholine, a key neurotransmitter involved in memory and learning. Multiple preclinical studies have demonstrated that Brahmi extracts can increase acetylcholine levels in the brain, primarily by inhibiting acetylcholinesterase, the enzyme responsible for breaking down acetylcholine. This mechanism is similar to some pharmaceutical drugs used in the management of Alzheimer’s disease.

Several animal studies have shown that Brahmi administration improves memory performance and increases acetylcholine content in regions of the brain associated with learning. Human clinical trials, though limited in number and size, suggest that Brahmi may improve certain aspects of cognitive function, such as memory acquisition and retention, in healthy adults and elderly subjects. However, the direct measurement of acetylcholine levels in humans following Brahmi supplementation is lacking, and most evidence relies on cognitive performance as an indirect marker.

In summary, there is moderate scientific evidence from preclinical and some clinical research indicating that Brahmi supports the acetylcholine system, justifying its use for cognitive support. However, larger and more rigorous human studies are needed for stronger validation.