Evidence supporting the use of: Citicholine
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Citicoline (also known as CDP-choline) is a precursor for the synthesis of the neurotransmitter acetylcholine, which plays a crucial role in memory, learning, and other cognitive functions. Scientific research supports its use for supporting the acetylcholine system in the body. Multiple clinical studies and reviews have demonstrated that citicoline increases brain levels of choline and acetylcholine, particularly in individuals with cognitive impairment, stroke, or traumatic brain injury. For example, a 2008 review in "CNS Drugs" concluded that citicoline improves cognitive performance and memory in patients with chronic cerebral disorders, likely due to enhanced acetylcholine synthesis and phospholipid metabolism.

Additionally, a 2012 double-blind, placebo-controlled study published in "Food and Nutrition Sciences" found that healthy adults who supplemented with citicoline showed improved attention and psychomotor speed, outcomes attributed to increased acetylcholine availability. While the strongest evidence exists for populations with neurological deficits, some evidence supports benefits in healthy individuals as well.

Overall, the scientific literature indicates that citicoline can support the acetylcholine system, particularly by providing choline for neurotransmitter synthesis and membrane repair. However, the precise cognitive benefits in healthy adults require further large-scale trials, which is why the evidence is rated a 4 rather than a 5.

More about Citicholine
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