Convolvulus prostratus (commonly known as Shankhpushpi) has a longstanding history of use in traditional Ayurvedic and Unani medicine for its purported cognitive-enhancing and neuroprotective properties. Traditionally, it is believed to act as a brain tonic, supporting memory, learning, and overall mental function. These traditional systems often attribute its effects to balancing neurotransmitters and supporting healthy nervous system function, which would implicitly include acetylcholine—a neurotransmitter essential for learning and memory.

However, while there is considerable mention of Convolvulus prostratus in classical Ayurvedic texts for improving intellect and cognitive capacity, direct scientific evidence specifically demonstrating its action on the acetylcholine system in humans is limited. Some preclinical studies (primarily in rodents) have shown that extracts of the plant may enhance memory and learning, with suggestions that these effects could be mediated by cholinergic mechanisms (i.e., increasing acetylcholine levels or activity). Nevertheless, robust clinical trials in humans are lacking, and the precise mechanisms—especially relating directly to acetylcholine—remain to be conclusively established.

In summary, the use of Convolvulus prostratus to support the acetylcholine body system is primarily justified by traditional use, with some preliminary animal data hinting at a possible mechanism, but direct scientific validation in humans is insufficient at this time.