Evidence supporting the use of: Gastrodin
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Gastrodin is a bioactive compound derived from the traditional Chinese medicinal herb Gastrodia elata. Its use for supporting the acetylcholine (ACh) system and cognitive function has gained attention due to emerging scientific research. Several preclinical studies, primarily in animal models, have indicated that gastrodin may have neuroprotective effects relevant to cholinergic neurotransmission. Specifically, gastrodin appears to inhibit acetylcholinesterase, the enzyme responsible for breaking down acetylcholine, thereby potentially increasing acetylcholine levels in the brain. Some studies also report that gastrodin can upregulate the expression of choline acetyltransferase, an enzyme critical for acetylcholine synthesis. Animal studies in models of Alzheimer’s disease and other forms of cognitive impairment have shown that gastrodin can improve learning and memory, possibly via modulation of the cholinergic system as well as by reducing oxidative stress and neuroinflammation. However, human clinical data are limited and generally of low methodological quality. While traditional use of Gastrodia elata in Chinese medicine is primarily for calming the liver and treating headaches or dizziness, its specific application for supporting the acetylcholine system is based more on modern pharmacological investigations than on historical precedent. In summary, gastrodin’s use to support the acetylcholine system is grounded in preclinical scientific studies, but robust clinical evidence in humans remains lacking. The current evidence base is promising but preliminary, warranting a moderate rating.

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