Evidence supporting the use of: Ginkgo biloba
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgo biloba is often included in supplements aimed at supporting cognitive function, partly because of its proposed effects on the acetylcholine system. Acetylcholine is a key neurotransmitter involved in memory and learning. Scientific studies have shown that Ginkgo biloba extracts may have a modest effect on cognitive performance, especially in older adults or those with mild cognitive impairment or dementia. Some preclinical research suggests that Ginkgo biloba can inhibit acetylcholinesterase, the enzyme responsible for breaking down acetylcholine, thereby potentially increasing acetylcholine levels in the brain. However, human studies specifically linking Ginkgo biloba to significant, clinically relevant increases in acetylcholine activity are limited and inconsistent.

While Ginkgo's antioxidant and vasodilatory properties are well-documented, evidence directly supporting its use to enhance the acetylcholine system is not robust. The majority of clinical trials have focused on broader cognitive outcomes rather than direct measures of acetylcholine or related biomarkers. As a result, the evidence base is considered weak to moderate (rated 2/5) for this specific application. Ginkgo biloba is used in both traditional and modern contexts for memory and cognitive support, but its direct role in modulating acetylcholine remains an area of ongoing research.

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