Hericenones are a group of compounds found in the fruiting body of the Lion's Mane mushroom (Hericium erinaceus). These compounds have attracted scientific interest for their potential neurotrophic effects, particularly their ability to stimulate the synthesis of nerve growth factor (NGF) in vitro and in animal models. NGF is important for the growth, maintenance, and survival of neurons, including cholinergic neurons that produce acetylcholine. Acetylcholine is a neurotransmitter crucial for memory and cognitive function.

Some preclinical studies suggest that hericenones may enhance NGF levels and exert neuroprotective effects, which could theoretically support acetylcholine-producing neurons. However, direct evidence that hericenones boost acetylcholine levels or function in humans is lacking. Most of the existing evidence comes from cell culture and animal studies, and the translation of these findings to human health is not yet established. A few small human clinical trials using Lion’s Mane mushroom extracts (which may contain hericenones) have reported improvements in cognitive function, but these studies are limited in scope and do not specifically link hericenones to acetylcholine metabolism.

In summary, while there is emerging scientific interest and some preliminary data, robust clinical evidence supporting hericenones specifically for acetylcholine system support is currently weak. More research, especially well-designed human trials, is needed to validate these effects.