Evidence supporting the use of: Vitamin B1 (fursultiamine)
For the body system: Acetylcholine

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fursultiamine is a synthetic derivative of thiamine (vitamin B1) developed to improve the bioavailability and cellular uptake of thiamine. Thiamine plays a critical role in glucose metabolism and is a cofactor for several enzymes involved in energy production, particularly in the brain. Acetylcholine synthesis requires acetyl-CoA, and thiamine-dependent enzymes such as pyruvate dehydrogenase are essential for generating acetyl-CoA from glucose metabolism. Thus, thiamine deficiency can indirectly impair acetylcholine production, leading to neurological symptoms, including cognitive dysfunction and disorders like Wernicke-Korsakoff syndrome. Fursultiamine, by providing a readily bioavailable form of thiamine, may help prevent or correct thiamine deficiency, thereby supporting acetylcholine synthesis indirectly. However, direct evidence that fursultiamine specifically enhances acetylcholine levels or cholinergic function in healthy individuals is limited. Most evidence comes from studies in the context of thiamine deficiency or neurological disorders. For example, some clinical studies have shown that thiamine or its derivatives improve cognitive function in patients with mild cognitive impairment or neurodegenerative disease, but these effects are generally modest and not specific to acetylcholine pathways. In summary, while there is a plausible biochemical rationale and some supportive evidence for the use of fursultiamine to support systems involving acetylcholine, the evidence is indirect and primarily relevant where thiamine deficiency is present. The overall scientific rating for this use is moderate to low.

More about Vitamin B1 (fursultiamine)
More about Acetylcholine

Other body systems supported by Vitamin B1 (fursultiamine)

Acetylcholine
Brain
Circulatory System
Gastrointestinal Tract
Heart
Liver
Muscles
Nerves

Products containing Vitamin B1 (fursultiamine)

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