Evidence supporting the use of: Vitamin B5 (calcium pantothenate)
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B5, also known as pantothenic acid (commonly provided as calcium pantothenate), plays an essential role in the synthesis of coenzyme A (CoA), a critical molecule in metabolism. Coenzyme A is directly involved in the acetylation of choline to form acetylcholine, a key neurotransmitter in the nervous system. Thus, adequate B5 is necessary for the biochemical pathway that produces acetylcholine.

However, while this biochemical role is well-established, there is limited direct scientific evidence that supplemental vitamin B5 (above normal dietary requirements) enhances acetylcholine production or function in healthy individuals. Most people obtain sufficient B5 from their diet, and deficiencies are rare. Animal studies and some in vitro research indicate that severe B5 deficiency can reduce acetylcholine synthesis, but robust clinical trials in humans demonstrating cognitive or neurological benefits from B5 supplementation are lacking.

In summary, the use of vitamin B5 to support the acetylcholine system is scientifically plausible based on biochemistry, but currently, evidence for a therapeutic benefit from supplementation (beyond correcting deficiency) is weak. Thus, the direct evidence for benefit in supporting the acetylcholine system is best rated as low to moderate.

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