Evidence supporting the use of: Vitamin B5 (Pantothenic Acid)
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pantothenic acid (Vitamin B5) plays a fundamental role in the synthesis of coenzyme A (CoA), which is crucial for numerous metabolic pathways, including the production of acetylcholine, a major neurotransmitter in the nervous system. CoA is directly involved in the acetylation of choline to form acetylcholine via the enzyme choline acetyltransferase. This biochemical connection is well-established and has been extensively characterized in cellular and animal studies. Deficiency of vitamin B5 can theoretically limit the availability of CoA, and therefore, impact acetylcholine synthesis. However, clinical deficiency of pantothenic acid is rare in humans due to its wide distribution in foods, and overt symptoms relating specifically to acetylcholine deficiency are not commonly reported. While there is a clear mechanistic link between B5 and acetylcholine synthesis, direct clinical evidence that supplemental B5 improves acetylcholine-related functions (such as memory or neuromuscular performance) in healthy or diseased humans is lacking. Most research supporting B5’s role is biochemical or based on animal models. Thus, while the use of pantothenic acid to support acetylcholine synthesis has a scientific basis, the quality and direct applicability of evidence to supplementation for enhancing the acetylcholine system in humans is limited.

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