Evidence supporting the use of: Waterhyssop
For the body system: Acetylcholine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Waterhyssop (Bacopa monnieri) has a long history of use in traditional Ayurvedic medicine for enhancing memory and cognitive function, which is now being explored through scientific study. Modern research provides some evidence that Bacopa monnieri may support the acetylcholine system, which is critical for learning and memory. Preclinical studies suggest that extracts of Bacopa monnieri can increase levels of acetylcholine in the brain by inhibiting acetylcholinesterase, the enzyme responsible for breaking down acetylcholine. For example, a 2008 study in Phytotherapy Research found that Bacopa extract administration increased acetylcholine content in rat brains. Human clinical trials, while generally focused on cognitive enhancement, also indirectly support acetylcholine involvement by demonstrating improved memory and attention in adults and the elderly after supplementation with Bacopa monnieri extract. However, while data from animal models is promising, direct high-quality human evidence specifically linking Bacopa’s effects to acetylcholine modulation is still limited. Most human studies use standardized extracts, such as Bacoside-A, and measure cognitive outcomes rather than neurotransmitter levels. In summary, there is scientific evidence, particularly from animal studies, supporting the role of waterhyssop in modulating the acetylcholine system, but more research in humans is needed to confirm these mechanisms.

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