False Calumba (Coscinium fenestratum) has been used traditionally in various systems of medicine, particularly in South and Southeast Asia, for digestive complaints including acid indigestion and dyspepsia. Ethnobotanical records indicate its use as a bitter tonic to stimulate appetite and improve digestion. These traditional uses are likely based on its bitter taste and presumed cholagogue (bile-stimulating) activity, which are thought in herbal medicine to aid in digestive processes and alleviate symptoms such as bloating and discomfort due to indigestion.

However, there is very limited scientific evidence directly evaluating the efficacy of False Calumba for acid indigestion. Most of the available research has focused on its antimicrobial, anti-inflammatory, and antioxidant properties, with few or no controlled clinical trials assessing its specific effects on gastric acidity or indigestion. Some phytochemical studies have identified the presence of berberine and related alkaloids, compounds known for their broad pharmacological effects, but not specifically for acid regulation.

In summary, while the use of False Calumba for acid indigestion is well-rooted in traditional practices, there is little robust scientific validation for this indication. Its use for this purpose should be considered as supported by tradition rather than by modern clinical evidence.