Aloe vera has been traditionally used for a variety of skin conditions, including acne, but in recent years there is a growing body of scientific evidence supporting its use as an adjunctive treatment for mild to moderate acne. Aloe vera gel contains several bioactive compounds such as polysaccharides, glycoproteins, vitamins, and minerals that contribute to its anti-inflammatory, antimicrobial, and wound-healing properties. These mechanisms are particularly relevant for acne, which involves inflammation, bacterial proliferation (notably Cutibacterium acnes), and skin barrier dysfunction.

Clinical studies have begun to examine aloe vera's efficacy for acne. For example, a randomized clinical trial published in Journal of Dermatological Treatment (2014) found that combining aloe vera gel with topical tretinoin was more effective and less irritating than tretinoin alone for mild to moderate acne. Another study (Journal of Clinical and Aesthetic Dermatology, 2021) supported the anti-inflammatory and antibacterial effects of aloe vera in reducing acne lesions.

While these findings are promising, most studies are small and use aloe vera in combination with standard acne treatments, rather than as a standalone therapy. Therefore, aloe vera is scientifically validated as a supportive, adjunctive remedy for acne, especially for its soothing and anti-inflammatory effects, but it is not considered a primary treatment. More large-scale, high-quality trials are needed to clarify its role.