Evidence supporting the use of: Azelaic acid
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Azelaic acid is scientifically validated for the treatment of acne. It is a naturally occurring dicarboxylic acid found in grains such as wheat, rye, and barley. Multiple randomized controlled trials and meta-analyses have established its efficacy in reducing both inflammatory and non-inflammatory acne lesions. Azelaic acid works through several mechanisms: it possesses antimicrobial properties (notably against Cutibacterium acnes and Staphylococcus epidermidis), reduces keratin production which can block pores, and exhibits anti-inflammatory effects. Additionally, azelaic acid has been shown to normalize the differentiation of skin cells and reduce the formation of comedones (clogged pores).

Clinical guidelines, including those from the American Academy of Dermatology, recommend azelaic acid (usually in 15-20% topical formulations) as a treatment option, especially for patients who cannot tolerate topical retinoids or benzoyl peroxide. Its safety profile is favorable, with minimal systemic absorption and few side effects, making it suitable for long-term use and for individuals with sensitive skin or during pregnancy (category B medication). Overall, the use of azelaic acid for acne is strongly supported by high-quality scientific evidence, and its efficacy and safety are well recognized in dermatological practice.

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Products containing Azelaic acid

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